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• W2896962148 abstract "At the earliest symptomatic stage of the disease, Mild Cognitive Impairment (MCI), Alzheimer's is typically classified as a problem of memory. However, it is known that MCI subjects develop difficulties in multiple areas of cognitive function, including those related to financial management. The Financial Capacity Instrument (FCI) is a performance based tool that has been shown to be effective in distinguishing diagnostic populations in a single site study. In light of this, the FCI Short Form (FCI-SF) has been incorporated into the Alzheimer's Disease Neuroimaging Initiative 3, or ADNI 3 (data collection and sharing funded by ADNI National Institutes of Health Grant U01 AG024904), in order to assess the test's capabilities on a multi-site level. Baseline clinical FCI-SF scores from 32 sites across the United States were summarized from ADNI 3 as of September 20, 2017. ANOVA comparisons for overall and sub-section scores were performed for normal controls (NC) (n=111), MCI patients (n=61), and mild Alzheimer's dementia (mAD) patients (n=11). Multiple comparisons analysis was performed at the item level to identify questions that separated the clinical sub-groups with the greatest significance. A significant separation in overall FCI-SF score (mean ± SE) was noted between NC (68.0 ± 0.51), MCI patients (58.8 ± 1.84) and mAD patients (39.5 ± 6.46). Clinical subpopulations were also significantly separated based on scores from each of the FCI-SF's five sub-sections, which include Mental Calculation, Financial Conceptual Knowledge, Single Checkbook/Register Task, Complex Checkbook/Register Task, and Bank Statement Management. Multiple comparisons analysis revealed that a subset of key items from Single and Complex Checkbook and Bank Statement Management subsections allowed for greatest separation of clinical subpopulations, particularly between NC and MCI. These data confirm that financial abilities decline in the earliest symptomatic stages of AD in a multiple-site setting. In addition to memory, early AD subjects develop deficits associated with a variety of complex tasks, highlighting functional deficits as an early feature of the disease." @default.
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• W2896962148 date "2018-07-01" @default.
• W2896962148 modified "2023-10-16" @default.
• W2896962148 title "P1‐361: ASSESSING FUNCTION IN EARLY AD: ANALYSIS OF ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE (ADNI) 3 DATA FOR THE FINANCIAL CAPACITY INSTRUMENT SHORT FORM (FCI‐SF)" @default.
• W2896962148 doi "https://doi.org/10.1016/j.jalz.2018.06.369" @default.
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