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• W2896963233 abstract "Most organisms must cope with temperature changes. This involves genes and gene networks both as subjects and agents of cellular protection, creating difficulties in understanding. Here, we study how heating and cooling affect expression of single genes and synthetic gene circuits in Saccharomyces cerevisiae . We discovered that nonoptimal temperatures induce a cell fate choice between stress resistance and growth arrest. This creates dramatic gene expression bimodality in isogenic cell populations, as arrest abolishes gene expression. Multiscale models incorporating population dynamics, temperature-dependent growth rates, and Arrhenius scaling of reaction rates captured the effects of cooling, but not those of heating in resistant cells. Molecular-dynamics simulations revealed how heating alters the conformational dynamics of the TetR repressor, fully explaining the experimental observations. Overall, nonoptimal temperatures induce a cell fate decision and corrupt gene and gene network function in computationally predictable ways, which may aid future applications of engineered microbes in nonstandard temperatures." @default.
• W2896963233 created "2018-10-26" @default.
• W2896963233 creator A5014308983 @default.
• W2896963233 creator A5033805877 @default.
• W2896963233 creator A5050076723 @default.
• W2896963233 creator A5047445142 @default.
• W2896963233 date "2018-10-19" @default.
• W2896963233 modified "2023-09-30" @default.
• W2896963233 title "Multiscale effects of heating and cooling on genes and gene networks" @default.
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• W2896963233 doi "https://doi.org/10.1073/pnas.1810858115" @default.
• W2896963233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6233105" @default.
• W2896963233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30341217" @default.
• W2896963233 hasPublicationYear "2018" @default.
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