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- W2896963556 abstract "Gastro-oesophageal reflux disease (GORD) is both common and troubling with a prevalence of 20-40%. We assessed the utility of a scintigraphic reflux study to evaluate the oesophageal and extra-oesophageal manifestation of disease compared to the standard tests such as pH monitoring and manometry.Patients were recruited into a prospective database of referrals to a tertiary referral center for either resistance to maximal medical therapy or extra-oesophageal symptoms of GORD. Data included 2 channel 24-hour pH monitoring and manometry results, as well as scintigraphic reflux data with late images assessing pulmonary aspiration of refluxate.Study population included 250 patients (155 F, 95 M) with an average age of 60 years. Patients were clinically classified as either GORD (n=72) or laryngopharyngeal reflux (LPR) (n=178). Pulmonary aspiration of the refluxate was detected significantly more commonly in LPR patients (58/178 compared with GORD 10/72). Strong correlations were found between the scintigraphic time-activity curves in the upper oesophagus and pharynx, and ineffective oesophageal motility and pulmonary aspiration. pH studies correlated with the scintigraphic studies but did not predict aspiration similar to other modalities when evaluated by ROC analysis.Scintigraphic reflux studies offer a viable alternative test for GORD and extra-oesophageal manifestations of reflux disease. Strong correlations were found between measurable scintigraphic parameters and oesophageal motility and lung aspiration of refluxate. This may provide a more confident decision analysis in patients being considered for fundoplication for troubling extra-oesophageal symptoms.Gastro-özofageal reflü (GÖR) hastalığı %20-40 arası prevalansı ile sık görülen bir sorundur. Bu çalışmada hastalığın özofageal ve özofagus dışı belirtilerini değerlendirmek için sintigrafik reflü testinin yararını inceleyerek bunu pH monitorizasyonu ve manometri gibi standart testlerle karşılaştırdık.Maksimal medikal tedavi veya GÖR özofagus-dışı belirtiler nedeniyle üçüncü basamak bir referans merkezine yönlendirilmiş hastalar prospektif veri tabanında toplandı. İki kanal 24-saat pH monitorizasyonu ve manometri sonuçları ile reflüksatın pulmoner aspirasyonunu değerlendiren geç görüntülerin dahil edildiği sintigrafik reflü verileri saptandı.Çalışmaya ortalama 60 yaşında 250 hasta (155 K, 95 E) dahil edildi. Hastalar klinik olarak ya GÖR (n=72) ya da laringofaringeal reflü (LPR) (n=178) olarak ikiye ayrıldı. Reflüksatın pulmoner aspirasyonu LPR hastalarında GÖR hastalarına göre anlamlı olarak daha sık saptandı (58/178’e vs. 10/72). Üst özofagus ile farinkste sintigrafik zaman-aktivite eğrileri arasında ve inefektif özofageal motilite ve pulmoner aspirasyon arasında ciddi korelasyon saptandı. pH testleri sintigrafik incelemelerle uyumlu idi ancak diğer incelemeler gibi ROC analizi ile değerlendirildiğinde sintigrafi de aspirasyonu öngöremedi.Sintigrafik reflü incelemeleri GÖR ve reflü hastalığının özofagus dışı belirtileri için yararlı bir alternatif testtir. Ölçülebilir sintigrafik parametreler ile özofagus motilitesi ve reflüksatın akciğer aspirasyonu arasında ciddi korelasyon saptanmıştır. Bu inceleme, özofagus dışı semptomu olan ve fundoplikasyon için değerlendirilen hastalarda ilgili karar verme sürecine katkı sağlayabilir." @default.
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- W2896963556 date "2018-10-01" @default.
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- W2896963556 title "Benchmarking of a Simple Scintigraphic Test for Gastro-oesophageal Reflux Disease That Assesses Oesophageal Disease and Its Pulmonary Complications" @default.
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- W2896963556 doi "https://doi.org/10.4274/mirt.10438" @default.
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