FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896966493> ?p ?o ?g. }

• W2896966493 endingPage "100" @default.
• W2896966493 startingPage "93" @default.
• W2896966493 abstract "Objective To evaluate microRNA (miRNA) biomarkers for upper tract urothelial carcinoma (UTUC) to improve risk stratification. Methods miRNA was isolated from 157 radical nephroureterectomy specimens from 2 institutions. The relative expression of miRNA was examined for high grade vs low grade tumors as well as muscle invasive vs nonmuscle invasive tumors. Recurrence free survival (RFS) and overall survival (OS) were also stratified using relative expression of specific miRNA. Results The optimized model to identify high grade UTUC included miR-29b-2-5p, miR-18a-5p, miR-223-3p, and miR-199a-5p, generating a sensitivity of 83%, specificity of 85%, and generated a receiver operating characteristic (ROC) curve with area-under-the-curve of 0.86. Similarly, the model classifier for predicting ≥pT2 disease incorporated miR-10b-5p, miR-26a-5p-5p, miR-31-5p, and miR-146b-5p, producing a sensitivity of 64%, specificity of 96%, and area-under-the-curve of 0.90. RFS was best reflected by a combination of miR-10a-5p, miR-30c-5p, and miR-10b-5p, while OS was best predicted by miR-10a-5p, miR-199a-5p, miR-30c-5p, and miR-10b-5p. Conclusion High-grade vs low-grade as well as muscle invasive vs nonmuscle invasive UTUC can be reliable distinguished with unique miRNA signatures. Furthermore, differential expression of UTUC miRNA produces robust classifiers for predicting RFS and OS that may help identify patients who would most benefit from adjuvant therapies." @default.
• W2896966493 created "2018-10-26" @default.
• W2896966493 creator A5016344156 @default.
• W2896966493 creator A5039232329 @default.
• W2896966493 creator A5039933301 @default.
• W2896966493 creator A5051762439 @default.
• W2896966493 creator A5060800293 @default.
• W2896966493 creator A5061244538 @default.
• W2896966493 creator A5064411059 @default.
• W2896966493 creator A5075648105 @default.
• W2896966493 creator A5076463164 @default.
• W2896966493 date "2019-01-01" @default.
• W2896966493 modified "2023-09-25" @default.
• W2896966493 title "MicroRNA Expression Profiles in Upper Tract Urothelial Carcinoma Differentiate Tumor Grade, Stage, and Survival: Implications for Clinical Decision-Making" @default.
• W2896966493 cites W1589295933 @default.
• W2896966493 cites W1971956251 @default.
• W2896966493 cites W1976434062 @default.
• W2896966493 cites W1980525903 @default.
• W2896966493 cites W1993427825 @default.
• W2896966493 cites W1998990473 @default.
• W2896966493 cites W2014326915 @default.
• W2896966493 cites W2016810184 @default.
• W2896966493 cites W2020541351 @default.
• W2896966493 cites W2026814692 @default.
• W2896966493 cites W2064482489 @default.
• W2896966493 cites W2065591646 @default.
• W2896966493 cites W2079479637 @default.
• W2896966493 cites W2085833972 @default.
• W2896966493 cites W2135810600 @default.
• W2896966493 cites W2171883057 @default.
• W2896966493 cites W2207322260 @default.
• W2896966493 cites W2295162151 @default.
• W2896966493 cites W2305693407 @default.
• W2896966493 cites W2341880944 @default.
• W2896966493 cites W2478136527 @default.
• W2896966493 cites W2590755345 @default.
• W2896966493 cites W2605734016 @default.
• W2896966493 cites W2614765431 @default.
• W2896966493 cites W2617547240 @default.
• W2896966493 cites W2736584458 @default.
• W2896966493 cites W2746490887 @default.
• W2896966493 cites W2793682041 @default.
• W2896966493 cites W3154088065 @default.
• W2896966493 cites W4249552371 @default.
• W2896966493 doi "https://doi.org/10.1016/j.urology.2018.10.004" @default.
• W2896966493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315887" @default.
• W2896966493 hasPublicationYear "2019" @default.
• W2896966493 type Work @default.
• W2896966493 sameAs 2896966493 @default.
• W2896966493 citedByCount "10" @default.
• W2896966493 countsByYear W28969664932019 @default.
• W2896966493 countsByYear W28969664932020 @default.
• W2896966493 countsByYear W28969664932021 @default.
• W2896966493 countsByYear W28969664932022 @default.
• W2896966493 crossrefType "journal-article" @default.
• W2896966493 hasAuthorship W2896966493A5016344156 @default.
• W2896966493 hasAuthorship W2896966493A5039232329 @default.
• W2896966493 hasAuthorship W2896966493A5039933301 @default.
• W2896966493 hasAuthorship W2896966493A5051762439 @default.
• W2896966493 hasAuthorship W2896966493A5060800293 @default.
• W2896966493 hasAuthorship W2896966493A5061244538 @default.
• W2896966493 hasAuthorship W2896966493A5064411059 @default.
• W2896966493 hasAuthorship W2896966493A5075648105 @default.
• W2896966493 hasAuthorship W2896966493A5076463164 @default.
• W2896966493 hasConcept C104317684 @default.
• W2896966493 hasConcept C121608353 @default.
• W2896966493 hasConcept C126322002 @default.
• W2896966493 hasConcept C126894567 @default.
• W2896966493 hasConcept C143998085 @default.
• W2896966493 hasConcept C145059251 @default.
• W2896966493 hasConcept C146357865 @default.
• W2896966493 hasConcept C151730666 @default.
• W2896966493 hasConcept C2777982462 @default.
• W2896966493 hasConcept C2778065480 @default.
• W2896966493 hasConcept C2779909341 @default.
• W2896966493 hasConcept C2780352672 @default.
• W2896966493 hasConcept C3019882237 @default.
• W2896966493 hasConcept C55493867 @default.
• W2896966493 hasConcept C58471807 @default.
• W2896966493 hasConcept C71924100 @default.
• W2896966493 hasConcept C76318530 @default.
• W2896966493 hasConcept C86803240 @default.
• W2896966493 hasConceptScore W2896966493C104317684 @default.
• W2896966493 hasConceptScore W2896966493C121608353 @default.
• W2896966493 hasConceptScore W2896966493C126322002 @default.
• W2896966493 hasConceptScore W2896966493C126894567 @default.
• W2896966493 hasConceptScore W2896966493C143998085 @default.
• W2896966493 hasConceptScore W2896966493C145059251 @default.
• W2896966493 hasConceptScore W2896966493C146357865 @default.
• W2896966493 hasConceptScore W2896966493C151730666 @default.
• W2896966493 hasConceptScore W2896966493C2777982462 @default.
• W2896966493 hasConceptScore W2896966493C2778065480 @default.
• W2896966493 hasConceptScore W2896966493C2779909341 @default.
• W2896966493 hasConceptScore W2896966493C2780352672 @default.
• W2896966493 hasConceptScore W2896966493C3019882237 @default.
• W2896966493 hasConceptScore W2896966493C55493867 @default.
• W2896966493 hasConceptScore W2896966493C58471807 @default.
• W2896966493 hasConceptScore W2896966493C71924100 @default.

• next