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• W2896966610 abstract "Human TSC2 gene, predisposing to a disease, Tuberous sclerosis complex (TSC), encodes a GTPase-activating protein for RHEB GTPase. Loss of TSC2 results in constitutive activation of RHEB and its target mTOR. We previously reported that fission yeast retrotransposons, Tf2s were abnormally induced upon nitrogen starvation in cells lacking tsc2+ gene (Δtsc2), a homolog of human TSC2 gene, and a dominant active mutant of fission yeast RHEB GTPase (rhb1-DA4). We report here that induction of Tf2s in these mutants is suppressed by overexpression of the cgs2+ gene encoding a cAMP-specific phosphodiesterase, or deletion of components in the glucose/cAMP signaling pathway, namely Cyr1, Pka1, Tor1 and a stress-activated transcription factor Atf1. The results suggest that the glucose/cAMP signaling pathway is down-regulated when cells are starved for nitrogen. We also show that Tf2s are degraded via autophagy, which is under control of Tor2, a homolog of human mTOR. It appears that failure in the two processes, downregulation of the glucose/cAMP signaling pathway and induction of autophagy, allows abnormal induction of Tf2s upon nitrogen starvation in Δtsc2 and rhb1-DA4." @default.
• W2896966610 created "2018-10-26" @default.
• W2896966610 creator A5036201256 @default.
• W2896966610 creator A5056826583 @default.
• W2896966610 date "2018-01-01" @default.
• W2896966610 modified "2023-09-23" @default.
• W2896966610 title "RHEB-mTOR axis regulates expression of transposons<i>Tf2</i>s in fission yeast." @default.
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• W2896966610 doi "https://doi.org/10.1242/jcs.221457" @default.
• W2896966610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301783" @default.
• W2896966610 hasPublicationYear "2018" @default.
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