Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896968424> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2896968424 endingPage "146" @default.
- W2896968424 startingPage "141" @default.
- W2896968424 abstract "Background: Experimental animal research has been pivotal in developing clinical kidney transplantation (KTx). One donor-associated risk factor with negative affect of transplantation outcome is brain death (BD). Many rat models for BD and KTx have been developed in the last decade, but no surgical guidelines have been developed for these models. Here, we describe a surgical technique for BD induction and the cuff technique for experimental KTx in rats.Methods: After intubation and mechanically ventilation of sixteen healthy adult male Sprague-Dawley rats were induction of BD performed. Animals were kept hemodynamically stable for eight hours. Then, the kidney was prepared and perfused with standard histidine-tryptophan-ketoglutarate solution. After explantation, grafts were immediately implanted in recipients using the cuff technique and reperfused. After 2 h of observation, animals were sacrificed by intravenous administration of potassium chloride.Results: In the early phase of BD, heart rate increased and mean arterial pressure decreased. Partial variations were observed in O2 partial pressure, O2 saturation, and HCO3. During the 2-h observation phase, all transplanted kidneys were sufficiently perfused macroscopically. There was no hyperacute rejection.Conclusions: It is feasible to observe BD for 8 h with maintained circulation in small experimental settings. The cuff technique for KTx is simple, the complication rate is low, and the warm ischemia time is short, therefore, this could be a suitable technique for KTx in the rat model." @default.
- W2896968424 created "2018-10-26" @default.
- W2896968424 creator A5005958530 @default.
- W2896968424 creator A5010846079 @default.
- W2896968424 creator A5013333802 @default.
- W2896968424 creator A5035346287 @default.
- W2896968424 creator A5037874477 @default.
- W2896968424 creator A5042634772 @default.
- W2896968424 creator A5066267790 @default.
- W2896968424 date "2018-10-18" @default.
- W2896968424 modified "2023-09-23" @default.
- W2896968424 title "Experimental Rat Model for Brain Death Induction and Kidney Transplantation" @default.
- W2896968424 cites W1964243071 @default.
- W2896968424 cites W1977954222 @default.
- W2896968424 cites W1990356393 @default.
- W2896968424 cites W2002158370 @default.
- W2896968424 cites W2006703657 @default.
- W2896968424 cites W2021470394 @default.
- W2896968424 cites W2078972976 @default.
- W2896968424 cites W2130861603 @default.
- W2896968424 cites W2139608316 @default.
- W2896968424 cites W2144069368 @default.
- W2896968424 cites W2144173525 @default.
- W2896968424 cites W2507591919 @default.
- W2896968424 cites W2586470520 @default.
- W2896968424 cites W2736214152 @default.
- W2896968424 cites W2740796892 @default.
- W2896968424 cites W2755248831 @default.
- W2896968424 cites W2755301912 @default.
- W2896968424 doi "https://doi.org/10.1080/08941939.2018.1480677" @default.
- W2896968424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30335532" @default.
- W2896968424 hasPublicationYear "2018" @default.
- W2896968424 type Work @default.
- W2896968424 sameAs 2896968424 @default.
- W2896968424 citedByCount "1" @default.
- W2896968424 countsByYear W28969684242022 @default.
- W2896968424 crossrefType "journal-article" @default.
- W2896968424 hasAuthorship W2896968424A5005958530 @default.
- W2896968424 hasAuthorship W2896968424A5010846079 @default.
- W2896968424 hasAuthorship W2896968424A5013333802 @default.
- W2896968424 hasAuthorship W2896968424A5035346287 @default.
- W2896968424 hasAuthorship W2896968424A5037874477 @default.
- W2896968424 hasAuthorship W2896968424A5042634772 @default.
- W2896968424 hasAuthorship W2896968424A5066267790 @default.
- W2896968424 hasConcept C126322002 @default.
- W2896968424 hasConcept C126894567 @default.
- W2896968424 hasConcept C141071460 @default.
- W2896968424 hasConcept C2780017030 @default.
- W2896968424 hasConcept C2780091579 @default.
- W2896968424 hasConcept C2780303639 @default.
- W2896968424 hasConcept C2911091166 @default.
- W2896968424 hasConcept C42219234 @default.
- W2896968424 hasConcept C71924100 @default.
- W2896968424 hasConceptScore W2896968424C126322002 @default.
- W2896968424 hasConceptScore W2896968424C126894567 @default.
- W2896968424 hasConceptScore W2896968424C141071460 @default.
- W2896968424 hasConceptScore W2896968424C2780017030 @default.
- W2896968424 hasConceptScore W2896968424C2780091579 @default.
- W2896968424 hasConceptScore W2896968424C2780303639 @default.
- W2896968424 hasConceptScore W2896968424C2911091166 @default.
- W2896968424 hasConceptScore W2896968424C42219234 @default.
- W2896968424 hasConceptScore W2896968424C71924100 @default.
- W2896968424 hasIssue "2" @default.
- W2896968424 hasLocation W28969684241 @default.
- W2896968424 hasLocation W28969684242 @default.
- W2896968424 hasOpenAccess W2896968424 @default.
- W2896968424 hasPrimaryLocation W28969684241 @default.
- W2896968424 hasRelatedWork W2016895065 @default.
- W2896968424 hasRelatedWork W2063513203 @default.
- W2896968424 hasRelatedWork W2091577046 @default.
- W2896968424 hasRelatedWork W2117376546 @default.
- W2896968424 hasRelatedWork W2135058494 @default.
- W2896968424 hasRelatedWork W2378019284 @default.
- W2896968424 hasRelatedWork W2379881079 @default.
- W2896968424 hasRelatedWork W2382568077 @default.
- W2896968424 hasRelatedWork W2888892896 @default.
- W2896968424 hasRelatedWork W3030709858 @default.
- W2896968424 hasVolume "33" @default.
- W2896968424 isParatext "false" @default.
- W2896968424 isRetracted "false" @default.
- W2896968424 magId "2896968424" @default.
- W2896968424 workType "article" @default.