FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896972411> ?p ?o ?g. }

• W2896972411 endingPage "1433" @default.
• W2896972411 startingPage "1425" @default.
• W2896972411 abstract "Liothyronine (LT3) has limited short-term clinical applications, all of which aim at suppressing thyrotropin (TSH) secretion. A more controversial application is chronic administration along with levothyroxine in the treatment of hypothyroidism. Long-term treatment with LT3 is complicated by its unique pharmacokinetics that result in a substantial triiodothyronine (T3) peak in the blood three to four hours after oral dosing. This is a significant problem, given that T3 levels in the blood are normally stable, varying by <10% throughout the day.A metal coordinated form of LT3 (Zn[T3][H2O])n, known as poly-zinc-liothyronine (PZL), was synthesized and loaded into coated gelatin capsules for delivery to the duodenum where sustained release of T3 from PZL occurs. Male Wistar rats were made hypothyroid by feeding on a low iodine diet and water containing 0.05% methimazole for five to six weeks. Rats were given a capsule containing 24 μg/kg PZL or equimolar amounts of LT3. Blood samples were obtained multiple times from the tail vein during the first 16 hours, and processed for T3 and TSH serum levels. Some animals were treated daily for eight days, and blood samples were collected daily.Rats given LT3 exhibited the expected serum T3 peak (about fivefold baseline) at 3.5 hours, followed by a rapid decline, with serum levels almost returning to baseline values by 16 hours. In contrast, serum T3 in PZL-treated rats exhibited about a 30% lower T3 peak at nine hours. Furthermore, the plateau time, that is, the time-span during which the serum T3 concentration is at least half of T3 peak, increased from 4.9 to 7.7 hours in LT3- versus PZL-treated rats, respectively. Serum TSH dropped in both groups, but PZL-treated rats exhibited a more gradual decrease, which was delayed by about four hours compared to LT3-treated rats. Chronic treatment with either LT3 or PZL restored growth, lowered serum cholesterol, and stimulated hepatic expression of the Dio1 mRNA and other T3-dependent markers in the central nervous system.Capsules of PZL given orally restore T3-dependent biological effects while exhibiting a reduced and delayed serum T3 peak after dosing, thus providing a longer period of relatively stable serum T3 levels compared to capsules of LT3." @default.
• W2896972411 created "2018-10-26" @default.
• W2896972411 creator A5013906711 @default.
• W2896972411 creator A5026395401 @default.
• W2896972411 creator A5044191707 @default.
• W2896972411 creator A5062951043 @default.
• W2896972411 creator A5073718834 @default.
• W2896972411 date "2018-11-01" @default.
• W2896972411 modified "2023-09-25" @default.
• W2896972411 title "Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats" @default.
• W2896972411 cites W1747119434 @default.
• W2896972411 cites W1755861491 @default.
• W2896972411 cites W1992692011 @default.
• W2896972411 cites W1992880394 @default.
• W2896972411 cites W2021314292 @default.
• W2896972411 cites W2021534182 @default.
• W2896972411 cites W2024747445 @default.
• W2896972411 cites W2048245477 @default.
• W2896972411 cites W2050323914 @default.
• W2896972411 cites W2063068406 @default.
• W2896972411 cites W2065359672 @default.
• W2896972411 cites W2073771274 @default.
• W2896972411 cites W2078264039 @default.
• W2896972411 cites W2083714907 @default.
• W2896972411 cites W2090755454 @default.
• W2896972411 cites W2104878795 @default.
• W2896972411 cites W2106695259 @default.
• W2896972411 cites W2108077562 @default.
• W2896972411 cites W2109458276 @default.
• W2896972411 cites W2134856350 @default.
• W2896972411 cites W2138756616 @default.
• W2896972411 cites W2148247134 @default.
• W2896972411 cites W2163820892 @default.
• W2896972411 cites W2199136101 @default.
• W2896972411 cites W2217176978 @default.
• W2896972411 cites W2319585632 @default.
• W2896972411 cites W2335515807 @default.
• W2896972411 cites W2336978010 @default.
• W2896972411 cites W2344105416 @default.
• W2896972411 cites W2347201063 @default.
• W2896972411 cites W2527838986 @default.
• W2896972411 cites W2759187279 @default.
• W2896972411 cites W2789751709 @default.
• W2896972411 cites W2808159488 @default.
• W2896972411 cites W4211084027 @default.
• W2896972411 doi "https://doi.org/10.1089/thy.2018.0205" @default.
• W2896972411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7207055" @default.
• W2896972411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301431" @default.
• W2896972411 hasPublicationYear "2018" @default.
• W2896972411 type Work @default.
• W2896972411 sameAs 2896972411 @default.
• W2896972411 citedByCount "17" @default.
• W2896972411 countsByYear W28969724112019 @default.
• W2896972411 countsByYear W28969724112020 @default.
• W2896972411 countsByYear W28969724112021 @default.
• W2896972411 countsByYear W28969724112022 @default.
• W2896972411 crossrefType "journal-article" @default.
• W2896972411 hasAuthorship W2896972411A5013906711 @default.
• W2896972411 hasAuthorship W2896972411A5026395401 @default.
• W2896972411 hasAuthorship W2896972411A5044191707 @default.
• W2896972411 hasAuthorship W2896972411A5062951043 @default.
• W2896972411 hasAuthorship W2896972411A5073718834 @default.
• W2896972411 hasBestOaLocation W28969724112 @default.
• W2896972411 hasConcept C126322002 @default.
• W2896972411 hasConcept C134018914 @default.
• W2896972411 hasConcept C2775883008 @default.
• W2896972411 hasConcept C2777195454 @default.
• W2896972411 hasConcept C2778288131 @default.
• W2896972411 hasConcept C2778778583 @default.
• W2896972411 hasConcept C526584372 @default.
• W2896972411 hasConcept C59822182 @default.
• W2896972411 hasConcept C71924100 @default.
• W2896972411 hasConcept C86803240 @default.
• W2896972411 hasConceptScore W2896972411C126322002 @default.
• W2896972411 hasConceptScore W2896972411C134018914 @default.
• W2896972411 hasConceptScore W2896972411C2775883008 @default.
• W2896972411 hasConceptScore W2896972411C2777195454 @default.
• W2896972411 hasConceptScore W2896972411C2778288131 @default.
• W2896972411 hasConceptScore W2896972411C2778778583 @default.
• W2896972411 hasConceptScore W2896972411C526584372 @default.
• W2896972411 hasConceptScore W2896972411C59822182 @default.
• W2896972411 hasConceptScore W2896972411C71924100 @default.
• W2896972411 hasConceptScore W2896972411C86803240 @default.
• W2896972411 hasIssue "11" @default.
• W2896972411 hasLocation W28969724111 @default.
• W2896972411 hasLocation W28969724112 @default.
• W2896972411 hasLocation W28969724113 @default.
• W2896972411 hasLocation W28969724114 @default.
• W2896972411 hasOpenAccess W2896972411 @default.
• W2896972411 hasPrimaryLocation W28969724111 @default.
• W2896972411 hasRelatedWork W1981780460 @default.
• W2896972411 hasRelatedWork W2020966517 @default.
• W2896972411 hasRelatedWork W2065348237 @default.
• W2896972411 hasRelatedWork W2066485846 @default.
• W2896972411 hasRelatedWork W2080164112 @default.
• W2896972411 hasRelatedWork W2082815614 @default.
• W2896972411 hasRelatedWork W2096059859 @default.
• W2896972411 hasRelatedWork W2106687377 @default.

• next