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- W2896974797 abstract "Functions of many long noncoding RNAs (lncRNAs) depend on their ability to interact with multiple copies of specific RNA-binding proteins (RBPs). Here, we devised a workflow combining bioinformatics and experimental validation steps to systematically identify RNAs capable of multivalent RBP recruitment. This uncovered a number of previously unknown transcripts encoding high-density RBP recognition arrays within genetically normal short tandem repeats. We show that a top-scoring hit in this screen, lncRNA PNCTR, contains hundreds of pyrimidine tract-binding protein (PTBP1)-specific motifs allowing it to sequester a substantial fraction of PTBP1 in a nuclear body called perinucleolar compartment. Importantly, PNCTR is markedly overexpressed in a variety of cancer cells and its downregulation is sufficient to induce programmed cell death at least in part by stimulating PTBP1 splicing regulation activity. This work expands our understanding of the repeat-containing fraction of the human genome and illuminates a novel mechanism driving malignant transformation of cancer cells." @default.
- W2896974797 created "2018-10-26" @default.
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- W2896974797 date "2018-11-01" @default.
- W2896974797 modified "2023-10-14" @default.
- W2896974797 title "A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival" @default.
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- W2896974797 cites W1975116894 @default.
- W2896974797 cites W1980652053 @default.
- W2896974797 cites W1985214157 @default.
- W2896974797 cites W1999728161 @default.
- W2896974797 cites W2000100263 @default.
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- W2896974797 cites W2008205503 @default.
- W2896974797 cites W2011657487 @default.
- W2896974797 cites W2021341670 @default.
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- W2896974797 cites W2038874091 @default.
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- W2896974797 doi "https://doi.org/10.1016/j.molcel.2018.08.041" @default.
- W2896974797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6224606" @default.
- W2896974797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30318443" @default.
- W2896974797 hasPublicationYear "2018" @default.
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