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- W2896975714 abstract "Mild acidity matrix, rich blood vessels and special biomarkers constitute the primary tumor microenvironment. Nanoparticles could change their physicochemical characteristics by functionalizing a series of moieties which is responsive towards pH or specific markers. So precise regulation of nanocarrier-based drug delivery systems by the tumor microenvironment has showed great potential for theranostics. Herein, we developed a smart nano delivery system STD-NM, showing tumor microenvironment responsive targeting, efficient drug delivery and precise evaluation of therapeutic effect in vivo. STD-NM kept in ‘stealth’ state in normal environment while ‘activated’ in the tumor acidic environment, which could show stability in blood circulation while deeply penetrate into tumor tissues. Additionally, STD-NM was designed with aggregation-induced emission (AIE) characteristic, of which the fluorescence ‘switch on’ when apoptosis taken place. Gene analysis by RNA-seq also confirmed a superior therapeutic effect of drug loaded STD-NM treatment. We envisioned the well-designed smart nano materials for drug delivery could open a new avenue in precisely tumor imaging and specific cancer therapeutics." @default.
- W2896975714 created "2018-10-26" @default.
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- W2896975714 date "2019-01-01" @default.
- W2896975714 modified "2023-10-16" @default.
- W2896975714 title "Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring" @default.
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- W2896975714 doi "https://doi.org/10.1016/j.biomaterials.2018.10.003" @default.
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