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• W2896979444 abstract "Purpose To quantitate lens nuclear opacity using long-range swept-source optical coherence tomography (SS-OCT) images and to evaluate the correlation of this method to Lens Opacities Classification System III (LOCS III) and a Scheimpflug imaging-based grading system (Pentacam Nuclear Stage function; PNS). Methods This study enrolled 120 participants (120 eyes) with age-related nuclear cataracts. The best-corrected visual acuity (BCVA), LOCS III nuclear opalescence (NO) and nuclear colour (NC) were obtained. The nuclear density measured using PNS function (ND PNS ) was recorded. Three successive series of long-range SS-OCT images were captured, and the nuclear region was analysed using ImageJ (NIH, Bethesda, Maryland, USA) to generate SS-OCT image-based nuclear density (ND SS-OCT ). The repeatability of ND SS-OCT measurement was evaluated using within-subject coefficient of variation (CV w ) and intraclass correlation coefficient (ICC). Correlations of ND SS-OCT with NO and NC, BCVA and ND PNS were analysed. According to the integrity of nucleus imaged by Pentacam, patients were divided into two groups, and the parameters were compared between groups. Results The CV w and ICC for ND SS-OCT measurement were 1.5 % and 0.994, respectively. The ND SS-OCT significantly correlated with NO (r=0.831), NC (r=0.873), BCVA (r=0.655) and ND PNS (r=0.891). The ND SS-OCT , NO and NC, and BCVA were significantly different between the two groups. Conclusion Lens nuclear opacity quantitation using long-range SS-OCT images was repeatable and correlated well with LOCS III and PNS function. The Scheimpflug principle had a limitation in imaging dense nucleus. Long-range SS-OCT seems more promising for objectively and quantitatively assessing lens nuclear opacity." @default.
• W2896979444 created "2018-10-26" @default.
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• W2896979444 date "2018-10-12" @default.
• W2896979444 modified "2023-10-18" @default.
• W2896979444 title "Lens nuclear opacity quantitation with long-range swept-source optical coherence tomography: correlation to LOCS III and a Scheimpflug imaging-based grading system" @default.
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• W2896979444 doi "https://doi.org/10.1136/bjophthalmol-2018-312661" @default.
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