FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896980519> ?p ?o ?g. }

• W2896980519 endingPage "146" @default.
• W2896980519 startingPage "142" @default.
• W2896980519 abstract "Low mitochondrial DNA copy number (mtDNA CN) has been associated with e.g. cancer, cardiovascular and autoimmune diseases. We aimed to study a potential association between mtDNA CN and rheumatoid arthritis (RA). The relative quantity of mitochondrial DNA compared to nuclear DNA was measured in peripheral white blood cells from 149 RA affected twin pairs and 1321 non-affected twin pairs. Multiple regression analysis including RA discordant twin pairs was performed in order to separate specific effects of RA and familial RA predisposition using non-RA affected twin pairs as reference group. In addition, we performed a twin pair level analysis including only RA discordant twin pairs evaluating the effect of cell type, auto antibodies and RA genetic risk factors. Both the RA twins and their non-affected co-twins had significantly lower mtDNA CN than non-affected twins (-28.7 and -23.1 mtDNA CN, respectively). Adjusting for cell count attenuated these differences (-23.1 mtDNA CN and -20.1 mtDNA CN respectively). Within RA discordant twin pairs PTPN22(T) positive RA twins had a significantly lower amount than their co-twins (-16.3 mtDNA CN). PTPN22(T) had no effect among twins from non-affected twin pairs. MtDNA CN is significantly lower in persons with established RA and in predisposed non-affected RA co-twins suggesting that mitochondrial variation may be involved in the RA disease pathways. Our results also suggest that the RA associated genetic risk factor, PTPN22(T), further decreases the mtDNA CN, but only in carriers with established RA." @default.
• W2896980519 created "2018-10-26" @default.
• W2896980519 creator A5005677115 @default.
• W2896980519 creator A5014389043 @default.
• W2896980519 creator A5017000677 @default.
• W2896980519 creator A5052975905 @default.
• W2896980519 creator A5063652834 @default.
• W2896980519 creator A5070347896 @default.
• W2896980519 creator A5090286433 @default.
• W2896980519 date "2019-01-01" @default.
• W2896980519 modified "2023-10-16" @default.
• W2896980519 title "White blood cell mitochondrial DNA copy number is decreased in rheumatoid arthritis and linked with risk factors. A twin study" @default.
• W2896980519 cites W1481432786 @default.
• W2896980519 cites W1598861942 @default.
• W2896980519 cites W1956475538 @default.
• W2896980519 cites W1963735805 @default.
• W2896980519 cites W1970168377 @default.
• W2896980519 cites W1970857726 @default.
• W2896980519 cites W1974276656 @default.
• W2896980519 cites W1979995829 @default.
• W2896980519 cites W1982189992 @default.
• W2896980519 cites W1982503419 @default.
• W2896980519 cites W1996220958 @default.
• W2896980519 cites W2000524781 @default.
• W2896980519 cites W2004093651 @default.
• W2896980519 cites W2023936987 @default.
• W2896980519 cites W2028934624 @default.
• W2896980519 cites W2033753616 @default.
• W2896980519 cites W2047463911 @default.
• W2896980519 cites W2050711948 @default.
• W2896980519 cites W2064341136 @default.
• W2896980519 cites W2069782147 @default.
• W2896980519 cites W2070890108 @default.
• W2896980519 cites W2076693703 @default.
• W2896980519 cites W2092071745 @default.
• W2896980519 cites W2092429916 @default.
• W2896980519 cites W2096022984 @default.
• W2896980519 cites W2096159510 @default.
• W2896980519 cites W2109291482 @default.
• W2896980519 cites W2112472085 @default.
• W2896980519 cites W2123752132 @default.
• W2896980519 cites W2128286895 @default.
• W2896980519 cites W2138775791 @default.
• W2896980519 cites W2152348310 @default.
• W2896980519 cites W2313462881 @default.
• W2896980519 cites W2346049904 @default.
• W2896980519 cites W2467803365 @default.
• W2896980519 cites W2547915966 @default.
• W2896980519 cites W2565497969 @default.
• W2896980519 cites W2594164805 @default.
• W2896980519 cites W2763236606 @default.
• W2896980519 cites W2941449697 @default.
• W2896980519 doi "https://doi.org/10.1016/j.jaut.2018.09.008" @default.
• W2896980519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30327147" @default.
• W2896980519 hasPublicationYear "2019" @default.
• W2896980519 type Work @default.
• W2896980519 sameAs 2896980519 @default.
• W2896980519 citedByCount "12" @default.
• W2896980519 countsByYear W28969805192019 @default.
• W2896980519 countsByYear W28969805192020 @default.
• W2896980519 countsByYear W28969805192021 @default.
• W2896980519 countsByYear W28969805192022 @default.
• W2896980519 crossrefType "journal-article" @default.
• W2896980519 hasAuthorship W2896980519A5005677115 @default.
• W2896980519 hasAuthorship W2896980519A5014389043 @default.
• W2896980519 hasAuthorship W2896980519A5017000677 @default.
• W2896980519 hasAuthorship W2896980519A5052975905 @default.
• W2896980519 hasAuthorship W2896980519A5063652834 @default.
• W2896980519 hasAuthorship W2896980519A5070347896 @default.
• W2896980519 hasAuthorship W2896980519A5090286433 @default.
• W2896980519 hasConcept C104317684 @default.
• W2896980519 hasConcept C126322002 @default.
• W2896980519 hasConcept C135763542 @default.
• W2896980519 hasConcept C153209595 @default.
• W2896980519 hasConcept C161890455 @default.
• W2896980519 hasConcept C169594400 @default.
• W2896980519 hasConcept C203014093 @default.
• W2896980519 hasConcept C24586158 @default.
• W2896980519 hasConcept C2777575956 @default.
• W2896980519 hasConcept C2779356809 @default.
• W2896980519 hasConcept C3017743773 @default.
• W2896980519 hasConcept C54355233 @default.
• W2896980519 hasConcept C67636389 @default.
• W2896980519 hasConcept C71924100 @default.
• W2896980519 hasConcept C86803240 @default.
• W2896980519 hasConceptScore W2896980519C104317684 @default.
• W2896980519 hasConceptScore W2896980519C126322002 @default.
• W2896980519 hasConceptScore W2896980519C135763542 @default.
• W2896980519 hasConceptScore W2896980519C153209595 @default.
• W2896980519 hasConceptScore W2896980519C161890455 @default.
• W2896980519 hasConceptScore W2896980519C169594400 @default.
• W2896980519 hasConceptScore W2896980519C203014093 @default.
• W2896980519 hasConceptScore W2896980519C24586158 @default.
• W2896980519 hasConceptScore W2896980519C2777575956 @default.
• W2896980519 hasConceptScore W2896980519C2779356809 @default.
• W2896980519 hasConceptScore W2896980519C3017743773 @default.
• W2896980519 hasConceptScore W2896980519C54355233 @default.
• W2896980519 hasConceptScore W2896980519C67636389 @default.

• next