Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896981861> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2896981861 abstract "Aβ and tau aggregation contribute to pathogenesis of Alzheimer's disease (AD). However, it is unclear whether Aβ plays only an early role, or whether ongoing engagement of infective Aβ prions continues with disease progression. Also, distinguishing between inert amyloids versus active spreading prions is difficult. Thus, we devised a rapid cellular bioassay, enabling a parallel comparison of tau and Aβ prion levels in postmortem human brain samples. All individuals had significant Aβ prion levels at death; interestingly the longest-lived individuals showed a slight reduction in post mortem Aβ prion levels. Tau prion levels showed a greater decrease with life span, and half of the >80 year-old patients had very low tau prion levels despite significant neurofibrillary tau deposits. This trend was observed over a wide range of etiological forms of AD. Thus, familial and sporadic AD can now be seen as a continuous spectrum, with the defining feature being the presence of active tau and Aβ prions. Furthermore, APOE ε4 alleles known to predispose towards AD appeared to increase tau but not Aβ prions in the elderly. These data illustrate the interplay between prion strain aggressiveness and host factors in defining longevity, and identify the prion form as a target for therapeutics." @default.
- W2896981861 created "2018-10-26" @default.
- W2896981861 creator A5005585024 @default.
- W2896981861 creator A5012540754 @default.
- W2896981861 creator A5012831794 @default.
- W2896981861 creator A5016495519 @default.
- W2896981861 creator A5018345023 @default.
- W2896981861 creator A5021623971 @default.
- W2896981861 creator A5023857050 @default.
- W2896981861 creator A5031692016 @default.
- W2896981861 creator A5035340732 @default.
- W2896981861 creator A5047141421 @default.
- W2896981861 creator A5047501916 @default.
- W2896981861 creator A5064422622 @default.
- W2896981861 creator A5066991343 @default.
- W2896981861 creator A5074694043 @default.
- W2896981861 creator A5084188800 @default.
- W2896981861 creator A5091904954 @default.
- W2896981861 date "2018-07-01" @default.
- W2896981861 modified "2023-10-16" @default.
- W2896981861 title "P4‐233: AGED ALZHEIMER'S DISEASE BRAINS EXHIBIT NUMEROUS Aβ BUT ONLY FEW TAU PRIONS" @default.
- W2896981861 doi "https://doi.org/10.1016/j.jalz.2018.07.054" @default.
- W2896981861 hasPublicationYear "2018" @default.
- W2896981861 type Work @default.
- W2896981861 sameAs 2896981861 @default.
- W2896981861 citedByCount "0" @default.
- W2896981861 crossrefType "journal-article" @default.
- W2896981861 hasAuthorship W2896981861A5005585024 @default.
- W2896981861 hasAuthorship W2896981861A5012540754 @default.
- W2896981861 hasAuthorship W2896981861A5012831794 @default.
- W2896981861 hasAuthorship W2896981861A5016495519 @default.
- W2896981861 hasAuthorship W2896981861A5018345023 @default.
- W2896981861 hasAuthorship W2896981861A5021623971 @default.
- W2896981861 hasAuthorship W2896981861A5023857050 @default.
- W2896981861 hasAuthorship W2896981861A5031692016 @default.
- W2896981861 hasAuthorship W2896981861A5035340732 @default.
- W2896981861 hasAuthorship W2896981861A5047141421 @default.
- W2896981861 hasAuthorship W2896981861A5047501916 @default.
- W2896981861 hasAuthorship W2896981861A5064422622 @default.
- W2896981861 hasAuthorship W2896981861A5066991343 @default.
- W2896981861 hasAuthorship W2896981861A5074694043 @default.
- W2896981861 hasAuthorship W2896981861A5084188800 @default.
- W2896981861 hasAuthorship W2896981861A5091904954 @default.
- W2896981861 hasConcept C142724271 @default.
- W2896981861 hasConcept C159047783 @default.
- W2896981861 hasConcept C169760540 @default.
- W2896981861 hasConcept C203014093 @default.
- W2896981861 hasConcept C2779134260 @default.
- W2896981861 hasConcept C2780942790 @default.
- W2896981861 hasConcept C3019804061 @default.
- W2896981861 hasConcept C502032728 @default.
- W2896981861 hasConcept C71924100 @default.
- W2896981861 hasConcept C86803240 @default.
- W2896981861 hasConceptScore W2896981861C142724271 @default.
- W2896981861 hasConceptScore W2896981861C159047783 @default.
- W2896981861 hasConceptScore W2896981861C169760540 @default.
- W2896981861 hasConceptScore W2896981861C203014093 @default.
- W2896981861 hasConceptScore W2896981861C2779134260 @default.
- W2896981861 hasConceptScore W2896981861C2780942790 @default.
- W2896981861 hasConceptScore W2896981861C3019804061 @default.
- W2896981861 hasConceptScore W2896981861C502032728 @default.
- W2896981861 hasConceptScore W2896981861C71924100 @default.
- W2896981861 hasConceptScore W2896981861C86803240 @default.
- W2896981861 hasIssue "7S_Part_29" @default.
- W2896981861 hasLocation W28969818611 @default.
- W2896981861 hasOpenAccess W2896981861 @default.
- W2896981861 hasPrimaryLocation W28969818611 @default.
- W2896981861 hasRelatedWork W1992945564 @default.
- W2896981861 hasRelatedWork W2146927838 @default.
- W2896981861 hasRelatedWork W2350671183 @default.
- W2896981861 hasRelatedWork W2351956356 @default.
- W2896981861 hasRelatedWork W2374607127 @default.
- W2896981861 hasRelatedWork W2420340464 @default.
- W2896981861 hasRelatedWork W2473391589 @default.
- W2896981861 hasRelatedWork W3029071291 @default.
- W2896981861 hasRelatedWork W3132681204 @default.
- W2896981861 hasRelatedWork W4313579270 @default.
- W2896981861 hasVolume "14" @default.
- W2896981861 isParatext "false" @default.
- W2896981861 isRetracted "false" @default.
- W2896981861 magId "2896981861" @default.
- W2896981861 workType "article" @default.