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• W2896984664 abstract "C-proteins control restriction–modification (R–M) systems’ genes transcription to ensure sufficient levels of restriction endonuclease to allow protection from foreign DNA while avoiding its modification by excess methyltransferase. Here, we characterize transcription regulation in C-protein dependent R–M system Kpn2I. The Kpn2I restriction endonuclease gene is transcribed from a constitutive, weak promoter, which, atypically, is C-protein independent. Kpn2I C-protein (C.Kpn2I) binds upstream of the strong methyltransferase gene promoter and inhibits it, likely by preventing the interaction of the RNA polymerase sigma subunit with the -35 consensus element. Diminished transcription from the methyltransferase promoter increases transcription from overlapping divergent C-protein gene promoters. All known C-proteins affect transcription initiation from R–M genes promoters. Uniquely, the C.Kpn2I binding site is located within the coding region of its gene. C.Kpn2I acts as a roadblock stalling elongating RNA polymerase and decreasing production of full-length C.Kpn2I mRNA. Mathematical modeling shows that this unusual mode of regulation leads to the same dynamics of accumulation of R–M gene transcripts as observed in systems where C-proteins act at transcription initiation stage only. Bioinformatics analyses suggest that transcription regulation through binding of C.Kpn2I-like proteins within the coding regions of their genes may be widespread." @default.
• W2896984664 created "2018-10-26" @default.
• W2896984664 creator A5013363397 @default.
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• W2896984664 creator A5083591986 @default.
• W2896984664 date "2018-10-08" @default.
• W2896984664 modified "2023-10-05" @default.
• W2896984664 title "Controller protein of restriction–modification system Kpn2I affects transcription of its gene by acting as a transcription elongation roadblock" @default.
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• W2896984664 doi "https://doi.org/10.1093/nar/gky880" @default.
• W2896984664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237814" @default.
• W2896984664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30295835" @default.
• W2896984664 hasPublicationYear "2018" @default.
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