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• W2896985898 abstract "Steroids exist universally and play critical roles in various biological processes. Identifying potential targets of steroids is of great significance in studying their physiological and biochemical activities, the side effects and for drug repurposing. Herein, aiming at more precise steroids targets prediction, a steroids-specific target library integrating 3325 PDB or homology modeling structures categorized into 196 proteins was built by considering chemical similarity from DrugBank and biological processes from KEGG. The main properties of this library include: (1) It was manually prepared and checked to eliminate mistakes. (2) The library enriched the possible steroids targets and could decrease the false positives of structure-based target screening for steroids. (3) The ranking by protein name instead of PDB ID could make the screening more efficiency and precise. (4) Protein flexibility was taken into account partially by the different active conformations through the structural redundancy of each category of protein, which leads to more accurate prediction. The case studies of glycocholic acid and 24-epibrassinolide proved its powerful predictive accuracy. In summary, our strategy to build the steroids-specific protein library for steroids target prediction is a promising approach and it provides a novel idea for the target prediction of small molecules." @default.
• W2896985898 created "2018-10-26" @default.
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• W2896985898 date "2018-12-01" @default.
• W2896985898 modified "2023-10-16" @default.
• W2896985898 title "Steroids-specific target library for steroids target prediction" @default.
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• W2896985898 cites W1947962437 @default.
• W2896985898 cites W1973444090 @default.
• W2896985898 cites W1976563274 @default.
• W2896985898 cites W1980969309 @default.
• W2896985898 cites W1985761301 @default.
• W2896985898 cites W1986191025 @default.
• W2896985898 cites W1988131660 @default.
• W2896985898 cites W1990170222 @default.
• W2896985898 cites W1992578437 @default.
• W2896985898 cites W1993554808 @default.
• W2896985898 cites W1997144569 @default.
• W2896985898 cites W2004323342 @default.
• W2896985898 cites W2008359658 @default.
• W2896985898 cites W2015642465 @default.
• W2896985898 cites W2017891440 @default.
• W2896985898 cites W2018518196 @default.
• W2896985898 cites W2019956253 @default.
• W2896985898 cites W2022513026 @default.
• W2896985898 cites W2025458374 @default.
• W2896985898 cites W2029197953 @default.
• W2896985898 cites W2033591223 @default.
• W2896985898 cites W2033777621 @default.
• W2896985898 cites W2038536040 @default.
• W2896985898 cites W2039299884 @default.
• W2896985898 cites W2040236971 @default.
• W2896985898 cites W2041133307 @default.
• W2896985898 cites W2043014029 @default.
• W2896985898 cites W2043382734 @default.
• W2896985898 cites W2044774776 @default.
• W2896985898 cites W2047157308 @default.
• W2896985898 cites W2052030759 @default.
• W2896985898 cites W2055147198 @default.
• W2896985898 cites W2057121933 @default.
• W2896985898 cites W2059074749 @default.
• W2896985898 cites W2062679933 @default.
• W2896985898 cites W2078653892 @default.
• W2896985898 cites W2092552275 @default.
• W2896985898 cites W2104916446 @default.
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• W2896985898 cites W2111157610 @default.
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• W2896985898 cites W2162320224 @default.
• W2896985898 cites W2169678694 @default.
• W2896985898 cites W2170146596 @default.
• W2896985898 cites W2171482501 @default.
• W2896985898 cites W2179066627 @default.
• W2896985898 cites W2262165342 @default.
• W2896985898 cites W2289490593 @default.
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• W2896985898 doi "https://doi.org/10.1016/j.steroids.2018.10.002" @default.
• W2896985898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30296544" @default.
• W2896985898 hasPublicationYear "2018" @default.
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