Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896987121> ?p ?o ?g. }
- W2896987121 endingPage "42" @default.
- W2896987121 startingPage "37" @default.
- W2896987121 abstract "Mice selected for high (HA) and low (LA) swim stress-induced analgesia (SSIA) are a unique model for studying the genetic background of this phenomenon. HA and LA miceshow substantial differences in the magnitude of the antinociceptive response to stress and when treated with exogenous opioids. However, the direct cause underplaying this distinctive feature has not yet been identified. The current study was designed to investigate the possibility that disturbances in G-protein signaling could explain the divergent response to opioid agonists. Supraspinal and spinal opioid sensitivity was assessed in vivo with intraperitoneal morphine and subsequent thermal stimulus exposure. The level of opioid receptor-mediated G-protein activation was investigated by means of DAMGO and morphine-stimulated [35S]GTPγS assay in the brain and spinal cord homogenates from HA and LA mice. Morphine (3–249 μmol/kg, i.p) was over 6 - and 3 - times more potent in HA than LA mice in the hot plate and tail-flick assays, respectively. Additionally, HA mice showed elevated β - endorphin levels in the brain. Enhanced efficacy of agonist-stimulated [35S]GTPγS binding was detected in opioid receptor-rich limbic regions of HA mice like the hypothalamus and hippocampus. Increased G-protein activity also emerged in the thalamus, periaqueductal gray matter and prefrontal cortex. In conclusion, the magnitude of the antinociceptive response to opioids in HA and LA mice is correlated with alterations in G-protein activation in brain regions responsible for integration and descending modulation of nociceptive information as well as at sites governing the emotional response to stressful stimuli." @default.
- W2896987121 created "2018-10-26" @default.
- W2896987121 creator A5033551710 @default.
- W2896987121 creator A5054226470 @default.
- W2896987121 creator A5063742203 @default.
- W2896987121 creator A5063916024 @default.
- W2896987121 creator A5087998951 @default.
- W2896987121 date "2019-01-01" @default.
- W2896987121 modified "2023-10-14" @default.
- W2896987121 title "Bidirectional selection for high and low stress-induced analgesia affects G-protein activity" @default.
- W2896987121 cites W1981223493 @default.
- W2896987121 cites W1983386270 @default.
- W2896987121 cites W1988927598 @default.
- W2896987121 cites W1990886374 @default.
- W2896987121 cites W1992220472 @default.
- W2896987121 cites W1993609532 @default.
- W2896987121 cites W1995346732 @default.
- W2896987121 cites W1997607195 @default.
- W2896987121 cites W1998353670 @default.
- W2896987121 cites W1999273832 @default.
- W2896987121 cites W2006032677 @default.
- W2896987121 cites W2019396061 @default.
- W2896987121 cites W2021291736 @default.
- W2896987121 cites W2024134608 @default.
- W2896987121 cites W2024897830 @default.
- W2896987121 cites W2029722158 @default.
- W2896987121 cites W2033987879 @default.
- W2896987121 cites W2034952894 @default.
- W2896987121 cites W2038684598 @default.
- W2896987121 cites W2039423720 @default.
- W2896987121 cites W2039772414 @default.
- W2896987121 cites W2044522616 @default.
- W2896987121 cites W2049476431 @default.
- W2896987121 cites W2051247780 @default.
- W2896987121 cites W2052049922 @default.
- W2896987121 cites W2066626861 @default.
- W2896987121 cites W2074558513 @default.
- W2896987121 cites W2077783303 @default.
- W2896987121 cites W2078757965 @default.
- W2896987121 cites W2085514581 @default.
- W2896987121 cites W2088337919 @default.
- W2896987121 cites W2093670138 @default.
- W2896987121 cites W2095036452 @default.
- W2896987121 cites W2098848290 @default.
- W2896987121 cites W2104168199 @default.
- W2896987121 cites W2115741564 @default.
- W2896987121 cites W2127373397 @default.
- W2896987121 cites W2128871031 @default.
- W2896987121 cites W2130593452 @default.
- W2896987121 cites W2292756635 @default.
- W2896987121 cites W2396403517 @default.
- W2896987121 cites W2418108084 @default.
- W2896987121 cites W2596109928 @default.
- W2896987121 cites W2760457051 @default.
- W2896987121 cites W2778561217 @default.
- W2896987121 cites W4233064078 @default.
- W2896987121 cites W4376848280 @default.
- W2896987121 doi "https://doi.org/10.1016/j.neuropharm.2018.10.014" @default.
- W2896987121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30326238" @default.
- W2896987121 hasPublicationYear "2019" @default.
- W2896987121 type Work @default.
- W2896987121 sameAs 2896987121 @default.
- W2896987121 citedByCount "10" @default.
- W2896987121 countsByYear W28969871212019 @default.
- W2896987121 countsByYear W28969871212020 @default.
- W2896987121 countsByYear W28969871212021 @default.
- W2896987121 countsByYear W28969871212022 @default.
- W2896987121 countsByYear W28969871212023 @default.
- W2896987121 crossrefType "journal-article" @default.
- W2896987121 hasAuthorship W2896987121A5033551710 @default.
- W2896987121 hasAuthorship W2896987121A5054226470 @default.
- W2896987121 hasAuthorship W2896987121A5063742203 @default.
- W2896987121 hasAuthorship W2896987121A5063916024 @default.
- W2896987121 hasAuthorship W2896987121A5087998951 @default.
- W2896987121 hasConcept C126322002 @default.
- W2896987121 hasConcept C134018914 @default.
- W2896987121 hasConcept C14397066 @default.
- W2896987121 hasConcept C15490471 @default.
- W2896987121 hasConcept C169760540 @default.
- W2896987121 hasConcept C170493617 @default.
- W2896987121 hasConcept C185592680 @default.
- W2896987121 hasConcept C2776401185 @default.
- W2896987121 hasConcept C2777389121 @default.
- W2896987121 hasConcept C2778938600 @default.
- W2896987121 hasConcept C2779886867 @default.
- W2896987121 hasConcept C2781063702 @default.
- W2896987121 hasConcept C2781069035 @default.
- W2896987121 hasConcept C529278444 @default.
- W2896987121 hasConcept C552161191 @default.
- W2896987121 hasConcept C71924100 @default.
- W2896987121 hasConcept C86803240 @default.
- W2896987121 hasConcept C98274493 @default.
- W2896987121 hasConceptScore W2896987121C126322002 @default.
- W2896987121 hasConceptScore W2896987121C134018914 @default.
- W2896987121 hasConceptScore W2896987121C14397066 @default.
- W2896987121 hasConceptScore W2896987121C15490471 @default.
- W2896987121 hasConceptScore W2896987121C169760540 @default.
- W2896987121 hasConceptScore W2896987121C170493617 @default.