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- W2896988656 abstract "Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by expansion of the CAG repeat in the huntingtin gene. HD is characterized clinically by progressive motor, cognitive and neuropsychiatric symptoms. There are currently no disease modifying treatments available for HD, and there is a great need for biomarkers to monitor disease progression and identify new targets for therapeutic intervention. Neuroimaging techniques provide a powerful tool for assessing disease pathology and progression in premanifest stages, before the onset of overt motor symptoms. Structural magnetic resonance imaging (MRI) is non-invasive imaging techniques which have been employed to study structural and microstructural changes in premanifest and manifest HD gene carriers. This chapter described structural imaging techniques and analysis methods employed across HD MRI studies. Current evidence for structural MRI abnormalities in HD, and associations between atrophy, structural white matter changes, iron deposition and clinical performance are discussed; together with the use of structural MRI measures as a diagnostic tool, to assess longitudinal changes, and as potential biomarkers and endpoints for clinical trials." @default.
- W2896988656 created "2018-10-26" @default.
- W2896988656 creator A5004209911 @default.
- W2896988656 creator A5015136173 @default.
- W2896988656 creator A5034248910 @default.
- W2896988656 date "2018-01-01" @default.
- W2896988656 modified "2023-09-25" @default.
- W2896988656 title "Structural Magnetic Resonance Imaging in Huntington's Disease" @default.
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