FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896989310> ?p ?o ?g. }

• W2896989310 abstract "Abstract Respiratory syncytial virus (RSV) is a common virus that can have varying effects ranging from mild cold-like symptoms to mortality depending on the age and immune status of the individual. We combined mathematical modeling using ordinary differential equations (ODEs) with measurement of RSV infection kinetics in primary well differentiated human airway epithelial (HAE) cultures in vitro and in immunocompetent and immunosuppressed cotton rats to glean mechanistic details that underlie RSV infection kinetics in the lung. Quantitative analysis of viral titer kinetics in our mathematical model showed that the elimination of infected cells by the adaptive immune response generates unique RSV titer kinetic features including a faster time scale of viral titer clearance than viral production, and a monotonic decrease in the peak RSV titer with decreasing inoculum dose. Parameter estimation in the ODE model using a non-linear mixed effects approach revealed a very low rate (average single cell lifetime > 10 days) of cell lysis by RSV before the adaptive immune response is initiated. Our model predicted negligible changes in the RSV titer kinetics on earlier days (< 5 d.p.i) but a slower decay in RSV titer in immunosuppressed cotton rats compared to that in non-suppressed cotton rats at later days (>5 d.p.i) in silico. These predictions were in excellent agreement with the experimental results. Our combined approach quantified the importance of the adaptive immune response in suppressing RSV infection in cotton rats, which could be useful in testing RSV vaccine candidates. Importance A major difficulty in developing vaccines against RSV infection is our rudimentary understanding of the mechanisms that underlie RSV infection. We addressed this challenge by developing a mechanistic computational model with predictive powers for describing RSV infection kinetics in cotton rats. The model was constructed synergistically with in vitro and in vivo measurements. The combined framework determined an important role for CD8+ T cells responses in reducing RSV titers in cotton rats. The framework can be used to design future experiments to elucidate mechanisms underlying RSV infection and test outcomes for potential vaccine candidates. In addition, estimation of the model parameters provides quantitative values for parameters of biological and clinical interest such as the replication rate of RSV, the death rate of infected cells, and the average number of new infections initiated by a single infected cell." @default.
• W2896989310 created "2018-10-26" @default.
• W2896989310 creator A5001627409 @default.
• W2896989310 creator A5002797648 @default.
• W2896989310 creator A5018978935 @default.
• W2896989310 creator A5026421736 @default.
• W2896989310 creator A5036139334 @default.
• W2896989310 creator A5038457970 @default.
• W2896989310 creator A5041412811 @default.
• W2896989310 creator A5049668799 @default.
• W2896989310 creator A5075056794 @default.
• W2896989310 creator A5079188549 @default.
• W2896989310 date "2018-10-24" @default.
• W2896989310 modified "2023-09-23" @default.
• W2896989310 title "Mathematical Modeling Identifies the Role of Adaptive Immunity as a Key Controller of Respiratory Syncytial Virus (RSV) Titer in Cotton Rats" @default.
• W2896989310 cites W1885197335 @default.
• W2896989310 cites W1970842087 @default.
• W2896989310 cites W1982388806 @default.
• W2896989310 cites W1989501142 @default.
• W2896989310 cites W1997527149 @default.
• W2896989310 cites W2003024951 @default.
• W2896989310 cites W2022098233 @default.
• W2896989310 cites W2022259512 @default.
• W2896989310 cites W2032828164 @default.
• W2896989310 cites W2040767617 @default.
• W2896989310 cites W2043519223 @default.
• W2896989310 cites W2061657962 @default.
• W2896989310 cites W2066243349 @default.
• W2896989310 cites W2099287117 @default.
• W2896989310 cites W2102146833 @default.
• W2896989310 cites W2109977701 @default.
• W2896989310 cites W2112639149 @default.
• W2896989310 cites W2114705914 @default.
• W2896989310 cites W2142847210 @default.
• W2896989310 cites W2146453977 @default.
• W2896989310 cites W2151212971 @default.
• W2896989310 cites W2161304688 @default.
• W2896989310 cites W2198743132 @default.
• W2896989310 cites W2347047438 @default.
• W2896989310 cites W2347182889 @default.
• W2896989310 cites W2411447930 @default.
• W2896989310 cites W2514321698 @default.
• W2896989310 cites W2586234859 @default.
• W2896989310 cites W2741511733 @default.
• W2896989310 cites W4211037481 @default.
• W2896989310 cites W4238063882 @default.
• W2896989310 doi "https://doi.org/10.1101/451716" @default.
• W2896989310 hasPublicationYear "2018" @default.
• W2896989310 type Work @default.
• W2896989310 sameAs 2896989310 @default.
• W2896989310 citedByCount "0" @default.
• W2896989310 crossrefType "posted-content" @default.
• W2896989310 hasAuthorship W2896989310A5001627409 @default.
• W2896989310 hasAuthorship W2896989310A5002797648 @default.
• W2896989310 hasAuthorship W2896989310A5018978935 @default.
• W2896989310 hasAuthorship W2896989310A5026421736 @default.
• W2896989310 hasAuthorship W2896989310A5036139334 @default.
• W2896989310 hasAuthorship W2896989310A5038457970 @default.
• W2896989310 hasAuthorship W2896989310A5041412811 @default.
• W2896989310 hasAuthorship W2896989310A5049668799 @default.
• W2896989310 hasAuthorship W2896989310A5075056794 @default.
• W2896989310 hasAuthorship W2896989310A5079188549 @default.
• W2896989310 hasBestOaLocation W28969893101 @default.
• W2896989310 hasConcept C105702510 @default.
• W2896989310 hasConcept C159047783 @default.
• W2896989310 hasConcept C193419808 @default.
• W2896989310 hasConcept C203014093 @default.
• W2896989310 hasConcept C2522874641 @default.
• W2896989310 hasConcept C2779341262 @default.
• W2896989310 hasConcept C32611913 @default.
• W2896989310 hasConcept C534529494 @default.
• W2896989310 hasConcept C86803240 @default.
• W2896989310 hasConcept C8891405 @default.
• W2896989310 hasConceptScore W2896989310C105702510 @default.
• W2896989310 hasConceptScore W2896989310C159047783 @default.
• W2896989310 hasConceptScore W2896989310C193419808 @default.
• W2896989310 hasConceptScore W2896989310C203014093 @default.
• W2896989310 hasConceptScore W2896989310C2522874641 @default.
• W2896989310 hasConceptScore W2896989310C2779341262 @default.
• W2896989310 hasConceptScore W2896989310C32611913 @default.
• W2896989310 hasConceptScore W2896989310C534529494 @default.
• W2896989310 hasConceptScore W2896989310C86803240 @default.
• W2896989310 hasConceptScore W2896989310C8891405 @default.
• W2896989310 hasLocation W28969893101 @default.
• W2896989310 hasLocation W28969893102 @default.
• W2896989310 hasOpenAccess W2896989310 @default.
• W2896989310 hasPrimaryLocation W28969893101 @default.
• W2896989310 hasRelatedWork W1529012375 @default.
• W2896989310 hasRelatedWork W1590546703 @default.
• W2896989310 hasRelatedWork W1978162700 @default.
• W2896989310 hasRelatedWork W2090477263 @default.
• W2896989310 hasRelatedWork W2165804863 @default.
• W2896989310 hasRelatedWork W2223869382 @default.
• W2896989310 hasRelatedWork W2289846861 @default.
• W2896989310 hasRelatedWork W2562955285 @default.
• W2896989310 hasRelatedWork W2766647135 @default.
• W2896989310 hasRelatedWork W573847062 @default.
• W2896989310 isParatext "false" @default.
• W2896989310 isRetracted "false" @default.
• W2896989310 magId "2896989310" @default.

• next