Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896996968> ?p ?o ?g. }
- W2896996968 endingPage "153303381880649" @default.
- W2896996968 startingPage "153303381880649" @default.
- W2896996968 abstract "Background and Purpose:The aim of this study was to investigate the survival outcomes and safety of hypofractioned stereotactic radiotherapy as a salvage treatment for recurrent high-grade glioma. Patients and Methods:Between March 2012 and March 2017, 32 consecutive patients (12 women, 20 men) treated in a single center were retrospectively included in this study. Grade III gliomas were diagnosed in 14 patients and grade IV in 18 patients. Thirty-four lesions were treated with hypofractionated stereotactic radiotherapy on a linear accelerator. Hypofractionated stereotactic radiotherapy delivered a median dose of 30 Gy (27-30) in 6 fractions (3-6) of 5 Gy (5-9). The treatment plans were normalized to 100% at the isocenter and prescribed to the 80% isodose line. Clinical outcomes and prognostic factors were analyzed. Results:Median follow-up was 20.9 months. Median overall survival following hypofractionated stereotactic radiotherapy was 15.6 months (median overall survival for patients with glioblastoma and grade III glioma was 8.2 and 19.5 months, respectively; P = .0496) and progression-free survival was 3.7 months (median progression-free survival for patients with glioblastoma and grade III glioma was 3.6 and 4.5 months, respectively; P = .2424). In multivariate analysis, tumor grade III (P = .0027), an Eastern Cooperative Oncology Group status <2 at the time of reirradiation (P = .0023), and a mean dose >35 Gy (P = .0055) significantly improved overall survival. A maximum reirradiation dose above 38 Gy (P = .0179) was significantly associated with longer progression-free survival. Conclusion:Hypofractionated stereotactic radiotherapy is well tolerated and offers an effective salvage option for the treatment of recurrent high-grade gliomas with encouraging overall survival. Our results suggest that the dose distribution had an impact on survival." @default.
- W2896996968 created "2018-10-26" @default.
- W2896996968 creator A5017413311 @default.
- W2896996968 creator A5020794024 @default.
- W2896996968 creator A5027049069 @default.
- W2896996968 creator A5054669965 @default.
- W2896996968 creator A5078065507 @default.
- W2896996968 creator A5079678693 @default.
- W2896996968 creator A5081036231 @default.
- W2896996968 date "2018-01-01" @default.
- W2896996968 modified "2023-09-27" @default.
- W2896996968 title "Hypofractionated Stereotactic Radiotherapy as a Salvage Therapy for Recurrent High-Grade Gliomas: Single-Center Experience" @default.
- W2896996968 cites W131934355 @default.
- W2896996968 cites W1479799490 @default.
- W2896996968 cites W1480523562 @default.
- W2896996968 cites W1571317512 @default.
- W2896996968 cites W1981424747 @default.
- W2896996968 cites W1983418949 @default.
- W2896996968 cites W1986583231 @default.
- W2896996968 cites W1990995664 @default.
- W2896996968 cites W1992949242 @default.
- W2896996968 cites W2010958887 @default.
- W2896996968 cites W2015546551 @default.
- W2896996968 cites W2020099494 @default.
- W2896996968 cites W2032971862 @default.
- W2896996968 cites W2036925578 @default.
- W2896996968 cites W2044013238 @default.
- W2896996968 cites W2044538065 @default.
- W2896996968 cites W2051187896 @default.
- W2896996968 cites W2057526131 @default.
- W2896996968 cites W2059624809 @default.
- W2896996968 cites W2063828422 @default.
- W2896996968 cites W2073649720 @default.
- W2896996968 cites W2076649680 @default.
- W2896996968 cites W2077597313 @default.
- W2896996968 cites W2077964273 @default.
- W2896996968 cites W2094621219 @default.
- W2896996968 cites W2096287682 @default.
- W2896996968 cites W2104352635 @default.
- W2896996968 cites W2110370693 @default.
- W2896996968 cites W2121396361 @default.
- W2896996968 cites W2124268471 @default.
- W2896996968 cites W2129874219 @default.
- W2896996968 cites W2133865472 @default.
- W2896996968 cites W2137686302 @default.
- W2896996968 cites W2137797918 @default.
- W2896996968 cites W2146756681 @default.
- W2896996968 cites W2147013683 @default.
- W2896996968 cites W2162709266 @default.
- W2896996968 cites W2188538530 @default.
- W2896996968 cites W2260733053 @default.
- W2896996968 cites W2279568831 @default.
- W2896996968 cites W2314733280 @default.
- W2896996968 cites W2366536035 @default.
- W2896996968 cites W2386703324 @default.
- W2896996968 cites W2431817062 @default.
- W2896996968 cites W2488750304 @default.
- W2896996968 cites W2530633099 @default.
- W2896996968 cites W2610403529 @default.
- W2896996968 cites W2732147664 @default.
- W2896996968 cites W3082730574 @default.
- W2896996968 doi "https://doi.org/10.1177/1533033818806498" @default.
- W2896996968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6198395" @default.
- W2896996968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30343637" @default.
- W2896996968 hasPublicationYear "2018" @default.
- W2896996968 type Work @default.
- W2896996968 sameAs 2896996968 @default.
- W2896996968 citedByCount "6" @default.
- W2896996968 countsByYear W28969969682019 @default.
- W2896996968 countsByYear W28969969682020 @default.
- W2896996968 countsByYear W28969969682022 @default.
- W2896996968 crossrefType "journal-article" @default.
- W2896996968 hasAuthorship W2896996968A5017413311 @default.
- W2896996968 hasAuthorship W2896996968A5020794024 @default.
- W2896996968 hasAuthorship W2896996968A5027049069 @default.
- W2896996968 hasAuthorship W2896996968A5054669965 @default.
- W2896996968 hasAuthorship W2896996968A5078065507 @default.
- W2896996968 hasAuthorship W2896996968A5079678693 @default.
- W2896996968 hasAuthorship W2896996968A5081036231 @default.
- W2896996968 hasBestOaLocation W28969969681 @default.
- W2896996968 hasConcept C126322002 @default.
- W2896996968 hasConcept C141071460 @default.
- W2896996968 hasConcept C143998085 @default.
- W2896996968 hasConcept C181401712 @default.
- W2896996968 hasConcept C2776694085 @default.
- W2896996968 hasConcept C2778120868 @default.
- W2896996968 hasConcept C2778227246 @default.
- W2896996968 hasConcept C2780073493 @default.
- W2896996968 hasConcept C2780387249 @default.
- W2896996968 hasConcept C2780739268 @default.
- W2896996968 hasConcept C2780775027 @default.
- W2896996968 hasConcept C2989005 @default.
- W2896996968 hasConcept C2992393070 @default.
- W2896996968 hasConcept C3019894029 @default.
- W2896996968 hasConcept C502942594 @default.
- W2896996968 hasConcept C509974204 @default.
- W2896996968 hasConcept C71924100 @default.
- W2896996968 hasConceptScore W2896996968C126322002 @default.