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- W2897003153 abstract "Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target is available yet. Our approach was to identify the epitope-based vaccine candidates as well as the ligand-binding pockets through the use of immunoinformatics. In this report, we identified both T-cell and B-cell epitopes of the most antigenic OROV polyprotein with the potential to induce both humoral and cell-mediated immunity. Eighteen highly antigenic and immunogenic CD8 + T-cell epitopes were identified, including three 100% conserved epitopes ( TSSWGCEEY , CSMCGLIHY , and LAIDTGCLY ) as the potential vaccine candidates. The selected epitopes showed 95.77% coverage for the mixed Brazilian population. The docking simulation ensured the binding interaction with high affinity. A total of five highly conserved and nontoxic linear B-cell epitopes “ NQKIDLSQL ,” “ HPLSTSQIGDRC ,” “ SHCNLEFTAITADKIMSL ,” “ PEKIPAKEGWLTFSKEHTSSW ,” and “ HHYKPTKNLPHVVPRYH ” were selected as potential vaccine candidates. The predicted eight conformational B-cell epitopes represent the accessibility for the entered virus. In the posttherapeutic strategy, ten ligand-binding pockets were identified for effective inhibitor design against emerging OROV infection. Collectively, this research provides novel candidates for epitope-based peptide vaccine design against OROV." @default.
- W2897003153 created "2018-10-26" @default.
- W2897003153 creator A5014119357 @default.
- W2897003153 creator A5026524483 @default.
- W2897003153 creator A5078065585 @default.
- W2897003153 date "2018-10-08" @default.
- W2897003153 modified "2023-10-16" @default.
- W2897003153 title "Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus" @default.
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