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- W2897015045 abstract "Significance Inflammatory processes drive the autoimmune disease multiple sclerosis (MS). However, what triggers this inflammation remains unknown. Several herpesviruses (HHVs), such as HHV-6 typically acquired during childhood, are associated with MS. The temporal separation between HHV-6 acquisition and MS development complicates its study as a disease trigger. Because rodents are not susceptible to HHV-6 infection, we utilized nonhuman primates to examine the impact of HHV-6 infection on an experimental MS-like disease. The viral infections were asymptomatic; however, the MS-like disease was significantly accelerated in all virally inoculated animals. Our data support the hypothesis that viruses may act as triggers to lower the threshold for autoimmunity, and warrant trials of antiviral interventions in early disease stages." @default.
- W2897015045 created "2018-10-26" @default.
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- W2897015045 date "2018-10-15" @default.
- W2897015045 modified "2023-10-17" @default.
- W2897015045 title "Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis" @default.
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- W2897015045 doi "https://doi.org/10.1073/pnas.1811974115" @default.
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