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• W2897019871 abstract "Uterine sarcoma is a rare disease with a poor prognosis, and its preoperative diagnosis is difficult. We previously presented the finding that a tumour with high tumour-to-subcutaneous fat signal intensity ratio on MRI T2 weighted imaging (TFSIR) and low ADC is highly suspected of sarcoma. But we have not reported our experience of clinical use as a preoperative prediction method yet. This time we re-examined the cut-off value of these parameters. The purpose of this study is to testify that these parameters are worthy of clinical use. MRI was performed in five cases of uterine sarcoma from 2014 for three years (sarcoma group), and in 64 cases of uterine benign tumour in 2015 and 2016 (myoma group) at our hospital. TFSIR and ADC were calculated and compared between two groups. The cut-off values of these parameters to predict sarcoma were also calculated. Then, preoperative prediction method by combination of these two parameters was considered. Finally, we applied this method for 38 uterine tumours in 2017 preoperatively, and matched the predictions to pathological results. The sarcoma group had significantly higher TFSIR than the myoma group (p<0.001). The minimum cut-off value of TFSIR to diagnose sarcoma was 0.515 (sensitivity: 100%, specificity: 88%). The sarcoma group had significantly lower ADC values than the leiomyoma group (p<0.001). The maximum cut-off value of ADC to diagnose sarcoma was 1.280 (sensitivity: 100%, specificity: 84%). All tumours with both positive TFSIR and ADC were sarcoma. The others ware benign tumour. We considered that tumour with both positive TFSIR and ADC is predicted as sarcoma. Among 38 uterine tumours in 2017, three tumours were predicted as sarcoma and two of those tumours were indeed sarcoma. Thus one false positive case resulted. All tumours predicted as benign tumour were indeed benign. Preoperative prediction of uterine sarcoma is possible using both TFSIR and ADC scores on MRI, whereas we have to be careful for false positive case. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
• W2897019871 created "2018-10-26" @default.
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• W2897019871 date "2018-10-01" @default.
• W2897019871 modified "2023-10-18" @default.
• W2897019871 title "OP08.03: Preoperative prediction of uterine sarcoma using T2 weighted imaging and apparent diffusion coefficient (ADC) on MRI and its clinical application" @default.
• W2897019871 doi "https://doi.org/10.1002/uog.19455" @default.
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