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- W2897022637 endingPage "103" @default.
- W2897022637 startingPage "89" @default.
- W2897022637 abstract "Platelets are anuclear blood cells required for haemostasis and are implicated in other processes including inflammation and metastasis. Platelets are produced by megakaryocytes, specialized cells that are themselves generated by a process of controlled differentiation and maturation of bone-marrow stem and progenitor cells. This process of megakaryopoiesis involves the coordinated interplay of transcription factor-controlled cellular programming with extra-cellular cues produced locally in supporting niches or as circulating factors. This review focuses on these external cues, the cytokines and chemokines, that drive production of megakaryocytes and support the terminal process of platelet release. Emphasis is given to thrombopoietin (Tpo), the major cytokine regulator of steady-state megakaryopoiesis, and its specific cell surface receptor, the Mpl protein, including normal and pathological roles as well as clinical application. The potential for alternative or supplementary regulatory mechanisms for platelet production, particularly in times of acute need, or in states of infection or inflammation are also discussed." @default.
- W2897022637 created "2018-10-26" @default.
- W2897022637 creator A5018104231 @default.
- W2897022637 creator A5058607130 @default.
- W2897022637 date "2018-07-04" @default.
- W2897022637 modified "2023-10-10" @default.
- W2897022637 title "Cytokine control of megakaryopoiesis" @default.
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