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• W2897033359 abstract "Aims Mutations of isocitrate dehydrogenase (IDH)1/2 affect almost all astrocytomas of WHO grade II and III. A subset of IDH-mutant astrocytic tumours progresses to IDH-mutant glioblastoma or presents with the histology of a glioblastoma at first presentation. We set out here to assess the molecular spectrum of IDH-mutant glioblastomas. Methods We performed an integrated molecular analysis of a mono-centric cohort (n = 97); assessed through genome-wide DNA methylation analysis, copy-number profiling and targeted next generation sequencing using a neurooncology-tailored gene panel. Results Of these 97 IDH-mutant glioblastomas, 68 had a glioblastoma at first presentation (‘de novo’ IDH-mutant glioblastoma) and 29 emerged from a prior low-grade lesion (‘evolved’ IDH-mutant glioblastoma). Unsupervised hierarchical clustering of DNA methylation data disclosed that IDH-mutant glioblastoma (‘de novo’ and ‘evolved’) formed a distinct group separate from other diffuse glioma subtypes. Homozygous deletions of CDKN2A/B were found to be associated with shorter survival. Conclusions This study demonstrates DNA methylation patterns in IDH-mutant glioblastoma to be distinct from lower-grade astrocytic counterparts but homogeneous within de novo and evolved IDH-mutant glioblastomas, and identifies CDKN2A as a marker for possible genetic sub-stratification." @default.
• W2897033359 created "2018-10-26" @default.
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• W2897033359 date "2018-11-15" @default.
• W2897033359 modified "2023-10-02" @default.
• W2897033359 title "Integrated molecular characterization of <i>IDH</i> -mutant glioblastomas" @default.
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• W2897033359 doi "https://doi.org/10.1111/nan.12523" @default.
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