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- W2897034850 abstract "18F-PM-PBB3 is unique among known Tau imaging agents as it has been shown to be useful for PET imaging of Tau lesions in both AD (3R + 4R) and progressive supranuclear palsy (4R) pathologies. Aprinoia, in collaborating with QST, has initiated global clinical studies with 18F-PM-PBB3 in the US, China, Japan and Taiwan. Aprinoia's development of the next generation PM-PBB3 binding-site focused tracer has led to the generation of a ∼1000 compound CNS-biased collection. This collection has been screened against other protein aggregates and targets to generate selective new leads. Here, we describe the screen of both tau and alpha-synuclein (aSyn) selective binding compounds via in vitro generated aSyn and Tau aggregated proteins. Our goal is to provide a single imaging compound able to image multi-isoforms of Tau across various tauopathies. Additionally, we hope to leverage our compound collection to generate tracers for other protein aggregates such as alpha-synuclein, TDP-43 etc to help facilitate diagnosis, track progression and assist clinical trials." @default.
- W2897034850 created "2018-10-26" @default.
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- W2897034850 date "2018-07-01" @default.
- W2897034850 modified "2023-10-16" @default.
- W2897034850 title "IC‐P‐082: TAU AND ALPHA‐SYNUCLEIN SELECTIVE BINDING COMPOUNDS DERIVED FROM APRINOIA THERAPEUTIC'S PM‐PBB3 BINDING‐SITE FOCUSED COMPOUND COLLECTION" @default.
- W2897034850 doi "https://doi.org/10.1016/j.jalz.2018.06.2146" @default.
- W2897034850 hasPublicationYear "2018" @default.
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