FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897035259> ?p ?o ?g. }

• W2897035259 abstract "The Circle of Willis (CoW) is comprised of seven arterial segments forming the main circulatory anastomosis distributing cerebral blood flow (CBF). The circle plays an essential role in both collateral circulation and as a pressure diffuser to protect downstream microvasculature from injury. Given that fully patent circles are uncommon and communicating arteries are the most commonly missing segments, this study examined their potential physiological significance. We investigate if missing the smallest CoW segments, including the anterior communicating artery (AcoA) and the posterior communicating arteries (PcoAs), relates to regional CBF alterations. Vanderbilt Memory & Aging Project participants free of clinical stroke and dementia were studied (n=314, 73±7 years, 58% male). Multimodal 3T brain MRI included magnetic resonance angiography (MRA) for examining the CoW patency and pseudo-continuous arterial spin labeling for quantifying resting CBF (mL/100g/min) for the frontal, temporal, parietal, and occipital lobes. Using MRA, the AcoA and two PcoA segments were manually coded as present or absent by a board-certified neuroradiologist. Linear regressions related AcoA and PcoA variants to CBF regions of interest (ROIs), adjusting for age, sex, race/ethnicity, education, Framingham Stroke Risk Profile, diagnosis, apolipoprotein E4 (APOE4) status, and ROI tissue volume. Missing at least one PcoA segment was prevalent in 37% of the cohort while a missing AcoA segment was prevalent in 9%. Missing at least one PcoA segment related to lower temporal lobe CBF (b=-2.11, p=0.03) but not frontal, parietal, or occipital CBF (p-values>0.07). A missing AcoA segment did not relate to any lobar CBF (p-values>0.05). Our results suggest that missing a PcoA segment appears to have regional associations with temporal lobe CBF, possibly reflecting early hemodynamic compromise that can result in subsequent microvascular damage in downstream tissue. In contrast, a missing AcoA did not relate to CBF. Unique CoW variations may be detrimental to brain health and further research is warranted to examine their clinical significance, including the impact of regional CBF changes on cognitive functions mediated by the temporal lobes." @default.
• W2897035259 created "2018-10-26" @default.
• W2897035259 creator A5006349365 @default.
• W2897035259 creator A5009545818 @default.
• W2897035259 creator A5015272640 @default.
• W2897035259 creator A5026142238 @default.
• W2897035259 creator A5036806288 @default.
• W2897035259 creator A5040701425 @default.
• W2897035259 creator A5051945922 @default.
• W2897035259 creator A5055091241 @default.
• W2897035259 creator A5055307922 @default.
• W2897035259 creator A5056115096 @default.
• W2897035259 creator A5057754328 @default.
• W2897035259 creator A5064323354 @default.
• W2897035259 creator A5065822809 @default.
• W2897035259 creator A5074132207 @default.
• W2897035259 creator A5074841252 @default.
• W2897035259 creator A5082948589 @default.
• W2897035259 creator A5086483278 @default.
• W2897035259 date "2018-07-01" @default.
• W2897035259 modified "2023-09-26" @default.
• W2897035259 title "P2‐354: POSTERIOR COMMUNICATING ARTERY VARIATION IN THE CIRCLE OF WILLIS IS ASSOCIATED WITH COMPROMISED TEMPORAL LOBE HEMODYNAMICS IN OLDER ADULTS" @default.
• W2897035259 doi "https://doi.org/10.1016/j.jalz.2018.06.1045" @default.
• W2897035259 hasPublicationYear "2018" @default.
• W2897035259 type Work @default.
• W2897035259 sameAs 2897035259 @default.
• W2897035259 citedByCount "0" @default.
• W2897035259 crossrefType "journal-article" @default.
• W2897035259 hasAuthorship W2897035259A5006349365 @default.
• W2897035259 hasAuthorship W2897035259A5009545818 @default.
• W2897035259 hasAuthorship W2897035259A5015272640 @default.
• W2897035259 hasAuthorship W2897035259A5026142238 @default.
• W2897035259 hasAuthorship W2897035259A5036806288 @default.
• W2897035259 hasAuthorship W2897035259A5040701425 @default.
• W2897035259 hasAuthorship W2897035259A5051945922 @default.
• W2897035259 hasAuthorship W2897035259A5055091241 @default.
• W2897035259 hasAuthorship W2897035259A5055307922 @default.
• W2897035259 hasAuthorship W2897035259A5056115096 @default.
• W2897035259 hasAuthorship W2897035259A5057754328 @default.
• W2897035259 hasAuthorship W2897035259A5064323354 @default.
• W2897035259 hasAuthorship W2897035259A5065822809 @default.
• W2897035259 hasAuthorship W2897035259A5074132207 @default.
• W2897035259 hasAuthorship W2897035259A5074841252 @default.
• W2897035259 hasAuthorship W2897035259A5082948589 @default.
• W2897035259 hasAuthorship W2897035259A5086483278 @default.
• W2897035259 hasConcept C118552586 @default.
• W2897035259 hasConcept C126322002 @default.
• W2897035259 hasConcept C126838900 @default.
• W2897035259 hasConcept C127413603 @default.
• W2897035259 hasConcept C143409427 @default.
• W2897035259 hasConcept C15744967 @default.
• W2897035259 hasConcept C164705383 @default.
• W2897035259 hasConcept C171614378 @default.
• W2897035259 hasConcept C178853913 @default.
• W2897035259 hasConcept C2775841333 @default.
• W2897035259 hasConcept C2776674566 @default.
• W2897035259 hasConcept C2777031167 @default.
• W2897035259 hasConcept C2777736543 @default.
• W2897035259 hasConcept C2778046553 @default.
• W2897035259 hasConcept C2778186239 @default.
• W2897035259 hasConcept C2778212899 @default.
• W2897035259 hasConcept C2778333808 @default.
• W2897035259 hasConcept C2778394091 @default.
• W2897035259 hasConcept C2780540156 @default.
• W2897035259 hasConcept C2780645631 @default.
• W2897035259 hasConcept C2780944724 @default.
• W2897035259 hasConcept C2781099131 @default.
• W2897035259 hasConcept C541997718 @default.
• W2897035259 hasConcept C71924100 @default.
• W2897035259 hasConcept C78519656 @default.
• W2897035259 hasConceptScore W2897035259C118552586 @default.
• W2897035259 hasConceptScore W2897035259C126322002 @default.
• W2897035259 hasConceptScore W2897035259C126838900 @default.
• W2897035259 hasConceptScore W2897035259C127413603 @default.
• W2897035259 hasConceptScore W2897035259C143409427 @default.
• W2897035259 hasConceptScore W2897035259C15744967 @default.
• W2897035259 hasConceptScore W2897035259C164705383 @default.
• W2897035259 hasConceptScore W2897035259C171614378 @default.
• W2897035259 hasConceptScore W2897035259C178853913 @default.
• W2897035259 hasConceptScore W2897035259C2775841333 @default.
• W2897035259 hasConceptScore W2897035259C2776674566 @default.
• W2897035259 hasConceptScore W2897035259C2777031167 @default.
• W2897035259 hasConceptScore W2897035259C2777736543 @default.
• W2897035259 hasConceptScore W2897035259C2778046553 @default.
• W2897035259 hasConceptScore W2897035259C2778186239 @default.
• W2897035259 hasConceptScore W2897035259C2778212899 @default.
• W2897035259 hasConceptScore W2897035259C2778333808 @default.
• W2897035259 hasConceptScore W2897035259C2778394091 @default.
• W2897035259 hasConceptScore W2897035259C2780540156 @default.
• W2897035259 hasConceptScore W2897035259C2780645631 @default.
• W2897035259 hasConceptScore W2897035259C2780944724 @default.
• W2897035259 hasConceptScore W2897035259C2781099131 @default.
• W2897035259 hasConceptScore W2897035259C541997718 @default.
• W2897035259 hasConceptScore W2897035259C71924100 @default.
• W2897035259 hasConceptScore W2897035259C78519656 @default.
• W2897035259 hasIssue "7S_Part_15" @default.
• W2897035259 hasLocation W28970352591 @default.
• W2897035259 hasOpenAccess W2897035259 @default.
• W2897035259 hasPrimaryLocation W28970352591 @default.
• W2897035259 hasRelatedWork W1965139409 @default.

• next