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• W2897036418 startingPage "R1242" @default.
• W2897036418 abstract "Expansion of extracellular fluid volume with crystalloid solutions is a common medical intervention, but its effects on renal cortical and medullary oxygenation are poorly understood. Therefore, we instrumented sheep under general anesthesia to enable continuous measurement of systemic and renal hemodynamics, global renal oxygen delivery and consumption, and intrarenal tissue perfusion and oxygen tension (Po 2 ) in conscious animals ( n = 7). The effects of three sequential intermittent infusions of 500 ml of compound sodium lactate solution, administered at hourly intervals, were determined. Volume expansion induced transient increases in mean arterial pressure (+7 ± 2%), central venous pressure (+50 ± 19%), and cardiac output (+15 ± 3%). There were sustained increases in renal medullary tissue Po 2 (+35 ± 10%) despite increases in global renal oxygen consumption (+66 ± 18%) and renal oxygen extraction (+64 ± 8%). Volume expansion did not significantly alter renal blood flow, renal oxygen delivery, or medullary perfusion. The sustained increase in medullary Po 2 was paralleled by increased bladder urine Po 2 (34 ± 4%). Cortical perfusion and Po 2 did not change significantly. Our findings indicate that extracellular fluid volume expansion can increase renal medullary oxygenation, providing a potential mechanistic basis for its use as prophylaxis against iatrogenic acute kidney injury. They also indicate that continuous measurement of bladder urine Po 2 could be used to monitor the effects of volume expansion on medullary oxygenation. However, the mechanisms mediating increased medullary oxygenation during volume expansion remain to be determined." @default.
• W2897036418 created "2018-10-26" @default.
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• W2897036418 date "2018-12-01" @default.
• W2897036418 modified "2023-10-01" @default.
• W2897036418 title "Alterations in regional kidney oxygenation during expansion of extracellular fluid volume in conscious healthy sheep" @default.
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• W2897036418 doi "https://doi.org/10.1152/ajpregu.00247.2018" @default.
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