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- W2897038510 abstract "Abstract Background Alcoholic liver disease (ALD) is one of the major cause of morbidity and mortality of clinical liver disease worldwide. Until today, although many general therapies are carried out and several molecular targets have been proposed to act as the potential therapeutic targets, more accurate molecular targets and more effective therapeutic methods remain needed. Material and Methods In the study, we analyze the differential expression genes (DEGs) between the patients with ALD and healthy controls. Gene Ontology enrichment and KEGG signaling pathway analysis are performed to identify the function of DEGs. Some significant molecules are proposed to act as the potential therapeutic targets for ALD. RNA data of 15 ALD tissues and 7 normal tissues for RNA expression analysis were obtained. DEGs in ALD samples compared with normal tissues identified through the limma R package and subjected to network analysis. Results As a result, we obtained a total of 274 DEGs that mainly involved in biological processes related to the angiogenesis, stress reaction, synthesis, and metabolism of organic acids. Network analysis obtained several genes with high network degree and fold change. Some significant molecules are proposed to act as the potential therapeutic targets for ALD. Conclusions Our research identified some new progression‐related genes of alcohol liver diseases, which could be regarded as the new targets for the early diagnosis and therapeutic management in ALD." @default.
- W2897038510 created "2018-10-26" @default.
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- W2897038510 date "2018-10-07" @default.
- W2897038510 modified "2023-10-17" @default.
- W2897038510 title "Comprehensive analysis of aberrantly expressed profiles of messenger RNA in alcoholic liver disease" @default.
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- W2897038510 doi "https://doi.org/10.1002/jcb.27710" @default.
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