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• W2897043556 abstract "Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene expression that is critical for determining the borders between genes. In budding yeast, termination at protein-coding genes is initiated by the cleavage/polyadenylation machinery, whereas termination of most noncoding RNA (ncRNA) genes occurs via the Nrd1-Nab3-Sen1 (NNS) pathway. Here, we find that NNS-like transcription termination is not conserved in fission yeast. Rather, genome-wide analyses show global recruitment of mRNA 3' end processing factors at the end of ncRNA genes, including snoRNAs and snRNAs, and that this recruitment coincides with high levels of Ser2 and Tyr1 phosphorylation on the RNAPII C-terminal domain. We also find that termination of mRNA and ncRNA transcription requires the conserved Ysh1/CPSF-73 and Dhp1/XRN2 nucleases, supporting widespread cleavage-dependent transcription termination in fission yeast. Our findings thus reveal that a common mode of transcription termination can produce functionally and structurally distinct types of polyadenylated and non-polyadenylated RNAs." @default.
• W2897043556 created "2018-10-26" @default.
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• W2897043556 date "2018-10-19" @default.
• W2897043556 modified "2023-10-17" @default.
• W2897043556 title "Common mechanism of transcription termination at coding and noncoding RNA genes in fission yeast" @default.
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• W2897043556 doi "https://doi.org/10.1038/s41467-018-06546-x" @default.
• W2897043556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195540" @default.
• W2897043556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30341288" @default.
• W2897043556 hasPublicationYear "2018" @default.
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