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• W2897043869 abstract "Brasilanones A–F and asperterreusines A–C, undescribed brasilane sesquiterpenoids and dihydrobenzofuran derivatives, were isolated from the marine-derived fungus Aspergillus terreus [CFCC 81836]. Their structures with absolute configurations were elucidated on the basis of spectroscopic data, X-ray crystallographic analyses, and electronic circular dichroism (ECD) calculations. Brasilanones A–F are unusual brasilane sesquiterpenoids with an α,β-unsaturated ketone unit, interestingly, brasilanones B–D are stereo isomers. All of the isolates were evaluated for their inhibitory activities against NO production and cytotoxic activities against five human cancer cell lines (HL-60, SW-480, A-549, MCF-7, and SMMC-7721). Brasilanones A and E showed moderate inhibitory effect with NO inhibition rates of 47.7% (p < 0.001) and 37.3% (p < 0.001) at the concentration of 40 μM. Asperterreusines A showed cytotoxicity against HL-60 and SW-480 cell lines with IC50 values of 15.3 and 25.7 μM, respectively." @default.
• W2897043869 created "2018-10-26" @default.
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• W2897043869 date "2018-12-01" @default.
• W2897043869 modified "2023-10-13" @default.
• W2897043869 title "Brasilane sesquiterpenoids and dihydrobenzofuran derivatives from Aspergillus terreus [CFCC 81836]" @default.
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• W2897043869 doi "https://doi.org/10.1016/j.phytochem.2018.10.006" @default.
• W2897043869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30308383" @default.
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