Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897044304> ?p ?o ?g. }
- W2897044304 abstract "Recent developments in nanotechnology have brought new approaches to cancer diagnosis and therapy. While enhanced permeability and retention effect promotes nano-chemotherapeutics extravasation, the abnormal tumor vasculature, high interstitial pressure and dense stroma structure limit homogeneous intratumoral distribution of nano-chemotherapeutics and compromise their imaging and therapeutic effect. Moreover, heterogeneous distribution of nano-chemotherapeutics in non-tumor-stroma cells damages the non-tumor cells, and interferes with tumor-stroma crosstalk. This can lead not only to inhibition of tumor progression, but can also paradoxically induce acquired resistance and facilitate tumor cell proliferation and metastasis. Overall, the tumor microenvironment plays a vital role in regulating nano-chemotherapeutics distribution and their biological effects. In this review, the barriers in tumor microenvironment, its consequential effects on nano-chemotherapeutics, considerations to improve nano-chemotherapeutics delivery and combinatory strategies to overcome acquired resistance induced by tumor microenvironment have been summarized. The various strategies viz., nanotechnology based approach as well as ligand-mediated, redox-responsive, and enzyme-mediated based combinatorial nanoapproaches have been discussed in this review." @default.
- W2897044304 created "2018-10-26" @default.
- W2897044304 creator A5003754883 @default.
- W2897044304 creator A5039067193 @default.
- W2897044304 creator A5084480385 @default.
- W2897044304 date "2018-10-31" @default.
- W2897044304 modified "2023-10-05" @default.
- W2897044304 title "Tumor Microenvironment Targeted Nanotherapy" @default.
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