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• W2897046087 abstract "Despite being an early event in ALS, it remains unclear whether the denervation of neuromuscular junctions (NMJ) is simply the first manifestation of a globally degenerating motor neuron. Using in vivo imaging of single axons and their NMJs over a three-month period, we identify that single motor-units are dismantled asynchronously in SOD1G37R mice. We reveal that weeks prior to complete axonal degeneration, the dismantling of axonal branches is accompanied by contemporaneous new axonal sprouting resulting in synapse formation onto nearby NMJs. Denervation events tend to propagate from the first lost NMJ, consistent with a contribution of neuromuscular factors extrinsic to motor neurons, with distal branches being more susceptible. These results show that NMJ denervation in ALS is a complex and dynamic process of continuous denervation and new innervation rather than a manifestation of sudden global motor neuron degeneration." @default.
• W2897046087 created "2018-10-26" @default.
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• W2897046087 date "2018-10-15" @default.
• W2897046087 modified "2023-10-13" @default.
• W2897046087 title "Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS" @default.
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• W2897046087 doi "https://doi.org/10.7554/elife.41973" @default.
• W2897046087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6234026" @default.
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• W2897046087 hasPublicationYear "2018" @default.
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