Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897046286> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2897046286 abstract "The concept of Subjective Cognitive Decline (SCD) has been proposed to tackle the prodromal phase of Alzheimer's disease (AD) and to identify individuals who are in the very early stages of the disease. Persons with SCD complain about their memory but do not show impairment on classical neuropsychological measures. Though they have a larger risk of progression to dementia than individuals without complaint, they likely represent a heterogeneous group of individuals. This complicates the interpretation of SCD and calls for further studies to characterize and validate the concept. One approach is to assess whether there is a relationship between pathological brain markers and cognition. 108 participants from the CIMA-Q cohort were included in the study: 58 with SCD, 25 with MCI, and 25 healthy controls (HC). Persons with SCD complained and were worried about their memory, although they were cognitively normal based on the Logical memory, Stroop, and Clinical Dementia Rating tests. All participants completed a clinical and cognitive battery and underwent a structural MRI. Group comparisons were done on tests of memory (Face-name association; Rey Auditory verbal learning test, RAVLT; Memoria Free recall) and tests of executive functions (Trail; Semantic fluency; Hayling) from the cognitive battery. Cognitive measures were then correlated with hippocampal volumes and white-matter hyperintensities (WMH). Individuals with SCD were unimpaired on measures of cognition relative to HC. However, their scores on the Memoria free recall and Face-name association tests correlated with right and left hippocampal volumes. The same tests correlated with the left hippocampal volume in participants with MCI. There was no correlation with hippocampal volume in HC. Fluency and Hayling correlated with WMH in individuals with SCD whereas Trail correlated with WMH in HC. The SCD group remains cognitively normal even when using sensitive measures of memory and executive functions. However, their hippocampal volumes were related to episodic memory, and WMH were related to executive functions. Similar findings were found for hippocampal volume in the MCI group. The results comfort the notion that SCD represents a valid research concept to better understand the prodromal phase of AD and other neurodegenerative diseases." @default.
- W2897046286 created "2018-10-26" @default.
- W2897046286 creator A5004394941 @default.
- W2897046286 creator A5010929089 @default.
- W2897046286 creator A5028869520 @default.
- W2897046286 creator A5032408530 @default.
- W2897046286 creator A5037076271 @default.
- W2897046286 creator A5049744616 @default.
- W2897046286 date "2018-07-01" @default.
- W2897046286 modified "2023-10-16" @default.
- W2897046286 title "P4‐089: THE RELATIONSHIP BETWEEN BRAIN MARKERS OF NEURODEGENERATION AND COGNITION IN PERSONS WITH SUBJECTIVE COGNITIVE DECLINE: A STUDY FROM THE CIMA‐Q COHORT" @default.
- W2897046286 doi "https://doi.org/10.1016/j.jalz.2018.06.2492" @default.
- W2897046286 hasPublicationYear "2018" @default.
- W2897046286 type Work @default.
- W2897046286 sameAs 2897046286 @default.
- W2897046286 citedByCount "0" @default.
- W2897046286 crossrefType "journal-article" @default.
- W2897046286 hasAuthorship W2897046286A5004394941 @default.
- W2897046286 hasAuthorship W2897046286A5010929089 @default.
- W2897046286 hasAuthorship W2897046286A5028869520 @default.
- W2897046286 hasAuthorship W2897046286A5032408530 @default.
- W2897046286 hasAuthorship W2897046286A5037076271 @default.
- W2897046286 hasAuthorship W2897046286A5049744616 @default.
- W2897046286 hasConcept C100660578 @default.
- W2897046286 hasConcept C126322002 @default.
- W2897046286 hasConcept C14216870 @default.
- W2897046286 hasConcept C15744967 @default.
- W2897046286 hasConcept C162967406 @default.
- W2897046286 hasConcept C169760540 @default.
- W2897046286 hasConcept C169900460 @default.
- W2897046286 hasConcept C172467417 @default.
- W2897046286 hasConcept C180747234 @default.
- W2897046286 hasConcept C2779134260 @default.
- W2897046286 hasConcept C2779483572 @default.
- W2897046286 hasConcept C2780046773 @default.
- W2897046286 hasConcept C2780906993 @default.
- W2897046286 hasConcept C2984863031 @default.
- W2897046286 hasConcept C2984915365 @default.
- W2897046286 hasConcept C548259974 @default.
- W2897046286 hasConcept C6057870 @default.
- W2897046286 hasConcept C71924100 @default.
- W2897046286 hasConcept C72563966 @default.
- W2897046286 hasConcept C88576662 @default.
- W2897046286 hasConcept C97530452 @default.
- W2897046286 hasConceptScore W2897046286C100660578 @default.
- W2897046286 hasConceptScore W2897046286C126322002 @default.
- W2897046286 hasConceptScore W2897046286C14216870 @default.
- W2897046286 hasConceptScore W2897046286C15744967 @default.
- W2897046286 hasConceptScore W2897046286C162967406 @default.
- W2897046286 hasConceptScore W2897046286C169760540 @default.
- W2897046286 hasConceptScore W2897046286C169900460 @default.
- W2897046286 hasConceptScore W2897046286C172467417 @default.
- W2897046286 hasConceptScore W2897046286C180747234 @default.
- W2897046286 hasConceptScore W2897046286C2779134260 @default.
- W2897046286 hasConceptScore W2897046286C2779483572 @default.
- W2897046286 hasConceptScore W2897046286C2780046773 @default.
- W2897046286 hasConceptScore W2897046286C2780906993 @default.
- W2897046286 hasConceptScore W2897046286C2984863031 @default.
- W2897046286 hasConceptScore W2897046286C2984915365 @default.
- W2897046286 hasConceptScore W2897046286C548259974 @default.
- W2897046286 hasConceptScore W2897046286C6057870 @default.
- W2897046286 hasConceptScore W2897046286C71924100 @default.
- W2897046286 hasConceptScore W2897046286C72563966 @default.
- W2897046286 hasConceptScore W2897046286C88576662 @default.
- W2897046286 hasConceptScore W2897046286C97530452 @default.
- W2897046286 hasIssue "7S_Part_28" @default.
- W2897046286 hasLocation W28970462861 @default.
- W2897046286 hasOpenAccess W2897046286 @default.
- W2897046286 hasPrimaryLocation W28970462861 @default.
- W2897046286 hasRelatedWork W1483188172 @default.
- W2897046286 hasRelatedWork W1994124622 @default.
- W2897046286 hasRelatedWork W2023161377 @default.
- W2897046286 hasRelatedWork W2110623487 @default.
- W2897046286 hasRelatedWork W2135825444 @default.
- W2897046286 hasRelatedWork W2321950773 @default.
- W2897046286 hasRelatedWork W2560640328 @default.
- W2897046286 hasRelatedWork W3095241819 @default.
- W2897046286 hasRelatedWork W3133680427 @default.
- W2897046286 hasRelatedWork W4211113674 @default.
- W2897046286 hasVolume "14" @default.
- W2897046286 isParatext "false" @default.
- W2897046286 isRetracted "false" @default.
- W2897046286 magId "2897046286" @default.
- W2897046286 workType "article" @default.