FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897047345> ?p ?o ?g. }

• W2897047345 endingPage "1801155" @default.
• W2897047345 startingPage "1801155" @default.
• W2897047345 abstract "Therapeutic nanocatalysis has emerged as an intriguing strategy for efficient cancer-specific therapy, but the traditional inorganic nanocatalysts suffer from low catalytic efficiency and difficulty in biodegradation, hindering their further clinical translation. Herein, a tumor microenvironment-triggered, biodegradable and biocompatible nanocatalyst employing 2D hydroxide nanosheet is presented, and is shown to have high catalytic capacity to efficiently produce abundant hydroxyl radicals under the tumor microenvironment and consequently kill tumor cells selectively. A polyethylene glycol (PEG)-conjugated Fe2+-containing hydroxide nanosheet is successfully constructed via a facile but efficient bottom-up approach that concurrently realizes nanosheet synthesis and PEGylation. Importantly, the nanosheets are featured with high catalytic activity to disproportionate H2O2 in tumors, and consequently generate abundant hydroxyl radicals at a high reaction rate under tumorous acidic condition; the highly toxic hydroxyl radicals, as a result, cause the death of tumor cells in vitro and suppress the tumor growth in vivo without the use of any supplementary toxic agent, only with the biocompatible nanocatalysts. Meanwhile, the desirable biodegradation and biocompatibility of the hydroxide nanosheet render a high degree of safety to the organism. Therefore, this work provides the first paradigm of biodegradable 2D nanocatalytic platform with concurrently high catalytic-therapeutic performance and biosafety for efficient tumor-specific treatment." @default.
• W2897047345 created "2018-10-26" @default.
• W2897047345 creator A5001395511 @default.
• W2897047345 creator A5004169900 @default.
• W2897047345 creator A5009700174 @default.
• W2897047345 creator A5023870393 @default.
• W2897047345 creator A5045621149 @default.
• W2897047345 creator A5063768932 @default.
• W2897047345 creator A5066599847 @default.
• W2897047345 creator A5075247746 @default.
• W2897047345 date "2018-10-09" @default.
• W2897047345 modified "2023-10-14" @default.
• W2897047345 title "Biodegradable 2D Fe-Al Hydroxide for Nanocatalytic Tumor-Dynamic Therapy with Tumor Specificity" @default.
• W2897047345 cites W1809723326 @default.
• W2897047345 cites W1980419364 @default.
• W2897047345 cites W1996990102 @default.
• W2897047345 cites W1997158168 @default.
• W2897047345 cites W2013967279 @default.
• W2897047345 cites W2020824171 @default.
• W2897047345 cites W2029871153 @default.
• W2897047345 cites W2035134488 @default.
• W2897047345 cites W2047522840 @default.
• W2897047345 cites W2047572502 @default.
• W2897047345 cites W2060264820 @default.
• W2897047345 cites W2065503102 @default.
• W2897047345 cites W2066411725 @default.
• W2897047345 cites W2068050569 @default.
• W2897047345 cites W2068072465 @default.
• W2897047345 cites W2072569792 @default.
• W2897047345 cites W2085060878 @default.
• W2897047345 cites W2086030168 @default.
• W2897047345 cites W2093889828 @default.
• W2897047345 cites W2124048728 @default.
• W2897047345 cites W2142574938 @default.
• W2897047345 cites W2146378598 @default.
• W2897047345 cites W2160771041 @default.
• W2897047345 cites W2165960269 @default.
• W2897047345 cites W2169419554 @default.
• W2897047345 cites W2170913114 @default.
• W2897047345 cites W2229268188 @default.
• W2897047345 cites W2246562916 @default.
• W2897047345 cites W2290132041 @default.
• W2897047345 cites W2291205197 @default.
• W2897047345 cites W2396166154 @default.
• W2897047345 cites W2418439740 @default.
• W2897047345 cites W2422872162 @default.
• W2897047345 cites W2560178729 @default.
• W2897047345 cites W2583207915 @default.
• W2897047345 cites W2604467403 @default.
• W2897047345 cites W2612586377 @default.
• W2897047345 cites W2614541421 @default.
• W2897047345 cites W2615993918 @default.
• W2897047345 cites W2621875781 @default.
• W2897047345 cites W2702254661 @default.
• W2897047345 cites W2718425322 @default.
• W2897047345 cites W2739603530 @default.
• W2897047345 cites W2741183871 @default.
• W2897047345 cites W2741371941 @default.
• W2897047345 cites W2745729112 @default.
• W2897047345 cites W2747084009 @default.
• W2897047345 cites W2787460561 @default.
• W2897047345 cites W2790338512 @default.
• W2897047345 cites W2793503277 @default.
• W2897047345 cites W2805919518 @default.
• W2897047345 cites W2897047345 @default.
• W2897047345 cites W4376634231 @default.
• W2897047345 doi "https://doi.org/10.1002/advs.201801155" @default.
• W2897047345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6247031" @default.
• W2897047345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30479938" @default.
• W2897047345 hasPublicationYear "2018" @default.
• W2897047345 type Work @default.
• W2897047345 sameAs 2897047345 @default.
• W2897047345 citedByCount "87" @default.
• W2897047345 countsByYear W28970473452019 @default.
• W2897047345 countsByYear W28970473452020 @default.
• W2897047345 countsByYear W28970473452021 @default.
• W2897047345 countsByYear W28970473452022 @default.
• W2897047345 countsByYear W28970473452023 @default.
• W2897047345 crossrefType "journal-article" @default.
• W2897047345 hasAuthorship W2897047345A5001395511 @default.
• W2897047345 hasAuthorship W2897047345A5004169900 @default.
• W2897047345 hasAuthorship W2897047345A5009700174 @default.
• W2897047345 hasAuthorship W2897047345A5023870393 @default.
• W2897047345 hasAuthorship W2897047345A5045621149 @default.
• W2897047345 hasAuthorship W2897047345A5063768932 @default.
• W2897047345 hasAuthorship W2897047345A5066599847 @default.
• W2897047345 hasAuthorship W2897047345A5075247746 @default.
• W2897047345 hasBestOaLocation W28970473451 @default.
• W2897047345 hasConcept C139066938 @default.
• W2897047345 hasConcept C161790260 @default.
• W2897047345 hasConcept C171250308 @default.
• W2897047345 hasConcept C178790620 @default.
• W2897047345 hasConcept C185592680 @default.
• W2897047345 hasConcept C192562407 @default.
• W2897047345 hasConcept C21951064 @default.
• W2897047345 hasConcept C2775896084 @default.
• W2897047345 hasConcept C2776107976 @default.
• W2897047345 hasConcept C2777230088 @default.

• next