FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897048380> ?p ?o ?g. }

• W2897048380 abstract "Aspergillus fumigatus is an environmental filamentous fungus that may act as an opportunistic pathogen causing a variety of diseases, including asthma or allergic bronchopulmonary aspergillosis, and infection, ranging from asymptomatic colonization to invasive pulmonary form, especially in immunocompromised patients. This fungus is characterized by different morphotypes including conidia which are the infective propagules able to germinate into hyphae. Due to their small size (2-3 µm), conidia released in the air can reach the lower respiratory tract. The objective of this study was to characterize the interactions between conidia and bronchial epithelial cells. To this end, we studied the role of bronchial epithelial cells, i.e., the BEAS-2B cell line and human primary cells, in conidial germination of a laboratory strain and three clinical strains of A. fumigatus. Microscopic observations and galactomannan measurements demonstrated that contact between epithelial cells and conidia leads to the inhibition of conidia germination. We demonstrated that this fungistatic process is not associated with the release of any soluble components nor internalization by the epithelial cells. We highlight that this antifungal process involves the phosphoinositide 3-kinase pathway on the host cellular side and the lectin FleA on the fungal side. Collectively, our results show that bronchial epithelial cells attenuate fungal virulence by inhibiting germination of extracellular conidia, thus preventing the morphological change from conidia to filaments, which is responsible for tissue invasion." @default.
• W2897048380 created "2018-10-26" @default.
• W2897048380 creator A5001025455 @default.
• W2897048380 creator A5007768330 @default.
• W2897048380 creator A5026297937 @default.
• W2897048380 creator A5028353199 @default.
• W2897048380 creator A5060714125 @default.
• W2897048380 creator A5066686177 @default.
• W2897048380 creator A5072318876 @default.
• W2897048380 creator A5075766838 @default.
• W2897048380 creator A5076515604 @default.
• W2897048380 creator A5086124216 @default.
• W2897048380 date "2018-10-24" @default.
• W2897048380 modified "2023-10-10" @default.
• W2897048380 title "Human Bronchial Epithelial Cells Inhibit Aspergillus fumigatus Germination of Extracellular Conidia via FleA Recognition" @default.
• W2897048380 cites W1562117121 @default.
• W2897048380 cites W1963838156 @default.
• W2897048380 cites W1977635065 @default.
• W2897048380 cites W1988354730 @default.
• W2897048380 cites W1999278724 @default.
• W2897048380 cites W2018644256 @default.
• W2897048380 cites W2021215684 @default.
• W2897048380 cites W2026399894 @default.
• W2897048380 cites W2029479476 @default.
• W2897048380 cites W2033179792 @default.
• W2897048380 cites W2039342879 @default.
• W2897048380 cites W2055143948 @default.
• W2897048380 cites W2057948698 @default.
• W2897048380 cites W2060136332 @default.
• W2897048380 cites W2061415739 @default.
• W2897048380 cites W2083601141 @default.
• W2897048380 cites W2089726284 @default.
• W2897048380 cites W2113311595 @default.
• W2897048380 cites W2115291382 @default.
• W2897048380 cites W2119409346 @default.
• W2897048380 cites W2124013631 @default.
• W2897048380 cites W2133094280 @default.
• W2897048380 cites W2143691385 @default.
• W2897048380 cites W2144728717 @default.
• W2897048380 cites W2147054709 @default.
• W2897048380 cites W2150980170 @default.
• W2897048380 cites W2152035287 @default.
• W2897048380 cites W2154922252 @default.
• W2897048380 cites W2157707867 @default.
• W2897048380 cites W2160898059 @default.
• W2897048380 cites W2164252368 @default.
• W2897048380 cites W2168917624 @default.
• W2897048380 cites W2329040846 @default.
• W2897048380 cites W2330949564 @default.
• W2897048380 cites W2423985041 @default.
• W2897048380 cites W2510557718 @default.
• W2897048380 cites W2555121231 @default.
• W2897048380 cites W2747923870 @default.
• W2897048380 cites W2753879303 @default.
• W2897048380 cites W2782834892 @default.
• W2897048380 cites W2793134738 @default.
• W2897048380 doi "https://doi.org/10.1038/s41598-018-33902-0" @default.
• W2897048380 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6200801" @default.
• W2897048380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30356167" @default.
• W2897048380 hasPublicationYear "2018" @default.
• W2897048380 type Work @default.
• W2897048380 sameAs 2897048380 @default.
• W2897048380 citedByCount "27" @default.
• W2897048380 countsByYear W28970483802019 @default.
• W2897048380 countsByYear W28970483802020 @default.
• W2897048380 countsByYear W28970483802021 @default.
• W2897048380 countsByYear W28970483802022 @default.
• W2897048380 countsByYear W28970483802023 @default.
• W2897048380 crossrefType "journal-article" @default.
• W2897048380 hasAuthorship W2897048380A5001025455 @default.
• W2897048380 hasAuthorship W2897048380A5007768330 @default.
• W2897048380 hasAuthorship W2897048380A5026297937 @default.
• W2897048380 hasAuthorship W2897048380A5028353199 @default.
• W2897048380 hasAuthorship W2897048380A5060714125 @default.
• W2897048380 hasAuthorship W2897048380A5066686177 @default.
• W2897048380 hasAuthorship W2897048380A5072318876 @default.
• W2897048380 hasAuthorship W2897048380A5075766838 @default.
• W2897048380 hasAuthorship W2897048380A5076515604 @default.
• W2897048380 hasAuthorship W2897048380A5086124216 @default.
• W2897048380 hasBestOaLocation W28970483801 @default.
• W2897048380 hasConcept C100701293 @default.
• W2897048380 hasConcept C104317684 @default.
• W2897048380 hasConcept C141105273 @default.
• W2897048380 hasConcept C159654299 @default.
• W2897048380 hasConcept C203014093 @default.
• W2897048380 hasConcept C2778871687 @default.
• W2897048380 hasConcept C2779678110 @default.
• W2897048380 hasConcept C2779787849 @default.
• W2897048380 hasConcept C28406088 @default.
• W2897048380 hasConcept C43143990 @default.
• W2897048380 hasConcept C55493867 @default.
• W2897048380 hasConcept C59822182 @default.
• W2897048380 hasConcept C60987743 @default.
• W2897048380 hasConcept C86803240 @default.
• W2897048380 hasConcept C89423630 @default.
• W2897048380 hasConcept C90080823 @default.
• W2897048380 hasConcept C95444343 @default.
• W2897048380 hasConceptScore W2897048380C100701293 @default.
• W2897048380 hasConceptScore W2897048380C104317684 @default.
• W2897048380 hasConceptScore W2897048380C141105273 @default.

• next