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- W2897049862 abstract "Abstract Objectives The dopaminergic pathway plays a vital role in pain expression. Here, our aim was to investigate the effects of polymorphisms in genes encoding the dopamine active transporter ( SLC 6A3 ) and dopamine receptor D2 ( DRD 2 ) on preoperative pain expression among patients preparing for orthopedic surgery. Methods Chinese elderly patients scheduled for orthopedic surgery were enrolled. The VAS was used to evaluate pain intensity (score range 0 to 10; 0 = no pain; 10 = worst pain possible). Depressive symptoms were evaluated via the 15‐item Geriatric Depression Scale. DNA was isolated from venous blood samples, and single‐nucleotide polymorphisms of SLC 6A3 and DRD 2 were genotyped. Multiple linear regressions analyses were carried out to adjust the results for confounders. Results A total of 294 patients with a mean age of 73.82 ± 8.03 years were enrolled in this study. After adjustment for confounders, rs393795 in SLC 6A3 showed a significant association with preoperative VAS scores. Patients with the A/A genotype reported lower mean pain scores than did those with the A/C genotype ( P = 0.026). Subsequent depression‐stratified analysis of rs6276 in DRD 2 revealed that patients with the A/A genotype had higher pain scores than did those with the G/G genotype ( P = 0.043). No associations were found for DRD 2 rs6277 in the whole study population or depression‐stratified groups. Conclusion Genetic variations in SLC 6A3 and DRD 2 may play an important role in pain expression among the elderly prior to orthopedic surgery." @default.
- W2897049862 created "2018-10-26" @default.
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- W2897049862 date "2018-11-11" @default.
- W2897049862 modified "2023-09-25" @default.
- W2897049862 title "Association Between Polymorphisms in Dopamine-Related Genes and Orthopedic Pain Expression in a Chinese Elderly Population" @default.
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- W2897049862 doi "https://doi.org/10.1111/papr.12737" @default.
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