FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897051658> ?p ?o ?g. }

• W2897051658 endingPage "4257" @default.
• W2897051658 startingPage "4249" @default.
• W2897051658 abstract "A random-sequence peptide microarray can interrogate serum antibodies in a broad, unbiased fashion to generate disease-specific immunosignatures. This approach has been applied to cancer detection, diagnosis of infections, and interrogation of vaccine response. We hypothesized that there is an immunosignature specific to ME/CFS and that this could aid in the diagnosis. We studied two subject groups meeting the Canadian Consensus Definition of ME/CFS. ME/CFS (n = 25) and matched control (n = 25) sera were obtained from a Canadian study. ME/CFS (n = 25) sera were obtained from phase 1/2 Norwegian trials (NCT01156909). Sera from six healthy controls from the USA were included in the analysis. Canadian cases and controls were tested for a disease immunosignature. By combining results from unsupervised and supervised analyses, a candidate immunosignature with 654 peptides was able to differentiate ME/CFS from controls. The immunosignature was tested and further refined using the Norwegian and USA samples. This resulted in a 256-peptide immunosignature with the ability to separate ME/CFS cases from controls in the international data sets. We were able to identify a 256-peptide signature that separates ME/CFS samples from healthy controls, suggesting that the hit-and-run hypothesis of immune dysfunction merits further investigation. By extending testing of both our signature and one previously reported in the literature to larger cohorts, and further interrogating the specific peptides we and others have identified, we may deepen our understanding of the origins of ME/CFS and work towards a clinically meaningful diagnostic biomarker." @default.
• W2897051658 created "2018-10-26" @default.
• W2897051658 creator A5003748765 @default.
• W2897051658 creator A5016467945 @default.
• W2897051658 creator A5024911686 @default.
• W2897051658 creator A5053343892 @default.
• W2897051658 creator A5066501041 @default.
• W2897051658 creator A5073415783 @default.
• W2897051658 creator A5078873032 @default.
• W2897051658 creator A5080118345 @default.
• W2897051658 creator A5083623904 @default.
• W2897051658 creator A5085588216 @default.
• W2897051658 date "2018-10-08" @default.
• W2897051658 modified "2023-10-18" @default.
• W2897051658 title "Immunosignature Analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)" @default.
• W2897051658 cites W1595840462 @default.
• W2897051658 cites W1774711529 @default.
• W2897051658 cites W1969689748 @default.
• W2897051658 cites W1970825432 @default.
• W2897051658 cites W1975319634 @default.
• W2897051658 cites W1994676162 @default.
• W2897051658 cites W2008087869 @default.
• W2897051658 cites W2009734258 @default.
• W2897051658 cites W2013074264 @default.
• W2897051658 cites W2034400748 @default.
• W2897051658 cites W2041818093 @default.
• W2897051658 cites W2043688086 @default.
• W2897051658 cites W2049978535 @default.
• W2897051658 cites W2106609323 @default.
• W2897051658 cites W2110408075 @default.
• W2897051658 cites W2113872014 @default.
• W2897051658 cites W2123629620 @default.
• W2897051658 cites W2137698397 @default.
• W2897051658 cites W2146512944 @default.
• W2897051658 cites W2155683866 @default.
• W2897051658 cites W2278607682 @default.
• W2897051658 cites W2400923684 @default.
• W2897051658 cites W2484065175 @default.
• W2897051658 cites W2509132807 @default.
• W2897051658 cites W2547768446 @default.
• W2897051658 cites W2566000666 @default.
• W2897051658 cites W2587139687 @default.
• W2897051658 cites W2604974649 @default.
• W2897051658 cites W2782472448 @default.
• W2897051658 cites W2911964244 @default.
• W2897051658 cites W3195769761 @default.
• W2897051658 cites W4294541781 @default.
• W2897051658 doi "https://doi.org/10.1007/s12035-018-1354-8" @default.
• W2897051658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6505503" @default.
• W2897051658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30298340" @default.
• W2897051658 hasPublicationYear "2018" @default.
• W2897051658 type Work @default.
• W2897051658 sameAs 2897051658 @default.
• W2897051658 citedByCount "10" @default.
• W2897051658 countsByYear W28970516582018 @default.
• W2897051658 countsByYear W28970516582019 @default.
• W2897051658 countsByYear W28970516582020 @default.
• W2897051658 countsByYear W28970516582021 @default.
• W2897051658 countsByYear W28970516582022 @default.
• W2897051658 countsByYear W28970516582023 @default.
• W2897051658 crossrefType "journal-article" @default.
• W2897051658 hasAuthorship W2897051658A5003748765 @default.
• W2897051658 hasAuthorship W2897051658A5016467945 @default.
• W2897051658 hasAuthorship W2897051658A5024911686 @default.
• W2897051658 hasAuthorship W2897051658A5053343892 @default.
• W2897051658 hasAuthorship W2897051658A5066501041 @default.
• W2897051658 hasAuthorship W2897051658A5073415783 @default.
• W2897051658 hasAuthorship W2897051658A5078873032 @default.
• W2897051658 hasAuthorship W2897051658A5080118345 @default.
• W2897051658 hasAuthorship W2897051658A5083623904 @default.
• W2897051658 hasAuthorship W2897051658A5085588216 @default.
• W2897051658 hasBestOaLocation W28970516581 @default.
• W2897051658 hasConcept C126322002 @default.
• W2897051658 hasConcept C138885662 @default.
• W2897051658 hasConcept C203014093 @default.
• W2897051658 hasConcept C2777899865 @default.
• W2897051658 hasConcept C2779134260 @default.
• W2897051658 hasConcept C2779566273 @default.
• W2897051658 hasConcept C2780640218 @default.
• W2897051658 hasConcept C2781197716 @default.
• W2897051658 hasConcept C41895202 @default.
• W2897051658 hasConcept C54355233 @default.
• W2897051658 hasConcept C60644358 @default.
• W2897051658 hasConcept C63428231 @default.
• W2897051658 hasConcept C71924100 @default.
• W2897051658 hasConcept C86803240 @default.
• W2897051658 hasConceptScore W2897051658C126322002 @default.
• W2897051658 hasConceptScore W2897051658C138885662 @default.
• W2897051658 hasConceptScore W2897051658C203014093 @default.
• W2897051658 hasConceptScore W2897051658C2777899865 @default.
• W2897051658 hasConceptScore W2897051658C2779134260 @default.
• W2897051658 hasConceptScore W2897051658C2779566273 @default.
• W2897051658 hasConceptScore W2897051658C2780640218 @default.
• W2897051658 hasConceptScore W2897051658C2781197716 @default.
• W2897051658 hasConceptScore W2897051658C41895202 @default.
• W2897051658 hasConceptScore W2897051658C54355233 @default.
• W2897051658 hasConceptScore W2897051658C60644358 @default.
• W2897051658 hasConceptScore W2897051658C63428231 @default.

• next