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- W2897051671 startingPage "860" @default.
- W2897051671 abstract "Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is predominantly induced postsynaptically, where mitochondria are understudied. Additionally, though mitochondrial fission is essential for their function, signaling pathways that regulate fission in neurons remain poorly understood. We found that NMDAR-dependent LTP induction prompted a rapid burst of dendritic mitochondrial fission and elevations of mitochondrial matrix Ca2+. The fission burst was triggered by cytosolic Ca2+ elevation and required CaMKII, actin, and Drp1, as well as dynamin 2. Preventing fission impaired mitochondrial matrix Ca2+ elevations, structural LTP in cultured neurons, and electrophysiological LTP in hippocampal slices. These data illustrate a novel pathway whereby synaptic activity controls mitochondrial fission and show that dynamic control of fission regulates plasticity induction, perhaps by modulating mitochondrial Ca2+ handling." @default.
- W2897051671 created "2018-10-26" @default.
- W2897051671 creator A5020220906 @default.
- W2897051671 creator A5022663641 @default.
- W2897051671 creator A5028162083 @default.
- W2897051671 creator A5033291364 @default.
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- W2897051671 creator A5065780835 @default.
- W2897051671 creator A5069755115 @default.
- W2897051671 creator A5084569687 @default.
- W2897051671 date "2018-11-01" @default.
- W2897051671 modified "2023-10-11" @default.
- W2897051671 title "Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction" @default.
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