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- W2897054128 abstract "Datasets reporting microRNA expression profiles in normal and cancer cells show that miR-216b is aberrantly downregulated in pancreatic ductal adenocarcinoma (PDAC). We found that KRAS, whose mutant G12D allele drives the pathogenesis of PDAC, is a target of miR-216b. To suppress oncogenic KRAS in PDAC cells, we designed single-stranded (ss) miR-216b mimics with unlocked nucleic acid (UNA) modifications to enhance their nuclease resistance. We prepared variants of ss-miR-216b mimics with and without a 5' phosphate group. Both variants strongly suppressed oncogenic KRAS in PDAC cells and inhibited colony formation in pancreatic cancer cells. We observed that the designed ss-miR-216b mimics engaged AGO2 to promote the silencing of KRAS. We also tested a new delivery strategy based on the use of palmityl-oleyl-phosphatidylcholine (POPC) liposomes functionalized with ss-miR-216b conjugated with two palmityl chains and a lipid-modified cell penetrating peptide (TAT). These versatile nanoparticles suppressed oncogenic KRAS in PDAC cells." @default.
- W2897054128 created "2018-10-26" @default.
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- W2897054128 date "2018-10-03" @default.
- W2897054128 modified "2023-09-24" @default.
- W2897054128 title "MicroRNA therapeutics: design of single-stranded miR-216b mimics to target <i>KRAS</i> in pancreatic cancer cells" @default.
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- W2897054128 doi "https://doi.org/10.1080/15476286.2018.1526536" @default.
- W2897054128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6284578" @default.
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