FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897054652> ?p ?o ?g. }

• W2897054652 endingPage "34" @default.
• W2897054652 startingPage "23" @default.
• W2897054652 abstract "Overexpression of the tight junction protein Junctional Adhesion Molecule-A (JAM-A) has been linked to aggressive disease in breast and other cancers, but JAM-targeting drugs remain elusive. Screening of a natural compound library identified the antibiotic Tetrocarcin-A as a novel downregulator of JAM-A and human epidermal growth factor receptor-2 (HER2) protein expression in breast cancer cells. Lysosomal inhibition partially rescued the downregulation of JAM-A and HER2 caused by Tetrocarcin-A, and attenuated its cytotoxic activity. Tetrocarcin-A treatment or JAM-A silencing reduced AKT and ERK phosphorylation, inhibited c-FOS phosphorylation at Threonine-232 (its transcriptional regulation site), inhibited nuclear localization of c-FOS, and downregulated expression of the inhibitor of apoptosis proteins (IAP). This was accompanied by Tetrocarcin-A-induced caspase-dependent apoptosis. To begin evaluating the potential clinical relevance of our findings, we extended our studies to other models. Encouragingly, Tetrocarcin-A downregulated JAM-A expression and caused cytotoxicity in primary breast cells and lung cancer stem cells, and inhibited the growth of xenografts in a semi-in vivo model involving invasion across the chicken egg chorioallantoic membrane. Taken together, our data suggest that Tetrocarcin-A warrants future evaluation as a novel cancer therapeutic by virtue of its ability to downregulate JAM-A expression, reduce tumorigenic signaling and induce apoptosis." @default.
• W2897054652 created "2018-10-26" @default.
• W2897054652 creator A5028101086 @default.
• W2897054652 creator A5028581226 @default.
• W2897054652 creator A5034513495 @default.
• W2897054652 creator A5037538488 @default.
• W2897054652 creator A5041891022 @default.
• W2897054652 creator A5056836900 @default.
• W2897054652 creator A5057975103 @default.
• W2897054652 date "2019-01-01" @default.
• W2897054652 modified "2023-09-25" @default.
• W2897054652 title "Natural compound Tetrocarcin-A downregulates Junctional Adhesion Molecule-A in conjunction with HER2 and inhibitor of apoptosis proteins and inhibits tumor cell growth" @default.
• W2897054652 cites W1580655877 @default.
• W2897054652 cites W1599411566 @default.
• W2897054652 cites W188996788 @default.
• W2897054652 cites W1964539791 @default.
• W2897054652 cites W1970010835 @default.
• W2897054652 cites W1981925980 @default.
• W2897054652 cites W1982024613 @default.
• W2897054652 cites W1985801265 @default.
• W2897054652 cites W1987441803 @default.
• W2897054652 cites W1994219871 @default.
• W2897054652 cites W1994599132 @default.
• W2897054652 cites W1996229838 @default.
• W2897054652 cites W2006043434 @default.
• W2897054652 cites W2010084552 @default.
• W2897054652 cites W2018105469 @default.
• W2897054652 cites W2019047953 @default.
• W2897054652 cites W2020771429 @default.
• W2897054652 cites W2024353883 @default.
• W2897054652 cites W2024430424 @default.
• W2897054652 cites W2027344970 @default.
• W2897054652 cites W2044312719 @default.
• W2897054652 cites W2050675499 @default.
• W2897054652 cites W2054717287 @default.
• W2897054652 cites W2058609749 @default.
• W2897054652 cites W2060798006 @default.
• W2897054652 cites W2063131548 @default.
• W2897054652 cites W2066571367 @default.
• W2897054652 cites W2071906362 @default.
• W2897054652 cites W2073183310 @default.
• W2897054652 cites W2078533623 @default.
• W2897054652 cites W2081184765 @default.
• W2897054652 cites W2087614230 @default.
• W2897054652 cites W2091270752 @default.
• W2897054652 cites W2095472210 @default.
• W2897054652 cites W2099695755 @default.
• W2897054652 cites W2100824883 @default.
• W2897054652 cites W2103179773 @default.
• W2897054652 cites W2109186855 @default.
• W2897054652 cites W2113943474 @default.
• W2897054652 cites W2119774224 @default.
• W2897054652 cites W2129883523 @default.
• W2897054652 cites W2131335999 @default.
• W2897054652 cites W2135743114 @default.
• W2897054652 cites W2145477245 @default.
• W2897054652 cites W2150438533 @default.
• W2897054652 cites W2151264766 @default.
• W2897054652 cites W2161659151 @default.
• W2897054652 cites W2169344919 @default.
• W2897054652 cites W2261991342 @default.
• W2897054652 cites W2288482051 @default.
• W2897054652 cites W2322383064 @default.
• W2897054652 cites W2401030151 @default.
• W2897054652 cites W2510069194 @default.
• W2897054652 cites W2606001457 @default.
• W2897054652 cites W2613784923 @default.
• W2897054652 cites W2740451900 @default.
• W2897054652 cites W2765641897 @default.
• W2897054652 cites W2782967188 @default.
• W2897054652 doi "https://doi.org/10.1016/j.canlet.2018.09.032" @default.
• W2897054652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30312728" @default.
• W2897054652 hasPublicationYear "2019" @default.
• W2897054652 type Work @default.
• W2897054652 sameAs 2897054652 @default.
• W2897054652 citedByCount "17" @default.
• W2897054652 countsByYear W28970546522019 @default.
• W2897054652 countsByYear W28970546522020 @default.
• W2897054652 countsByYear W28970546522021 @default.
• W2897054652 countsByYear W28970546522022 @default.
• W2897054652 countsByYear W28970546522023 @default.
• W2897054652 crossrefType "journal-article" @default.
• W2897054652 hasAuthorship W2897054652A5028101086 @default.
• W2897054652 hasAuthorship W2897054652A5028581226 @default.
• W2897054652 hasAuthorship W2897054652A5034513495 @default.
• W2897054652 hasAuthorship W2897054652A5037538488 @default.
• W2897054652 hasAuthorship W2897054652A5041891022 @default.
• W2897054652 hasAuthorship W2897054652A5056836900 @default.
• W2897054652 hasAuthorship W2897054652A5057975103 @default.
• W2897054652 hasBestOaLocation W28970546521 @default.
• W2897054652 hasConcept C104317684 @default.
• W2897054652 hasConcept C119056186 @default.
• W2897054652 hasConcept C11960822 @default.
• W2897054652 hasConcept C121608353 @default.
• W2897054652 hasConcept C127561419 @default.
• W2897054652 hasConcept C16224149 @default.
• W2897054652 hasConcept C185592680 @default.
• W2897054652 hasConcept C190283241 @default.

• next