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- W2897054691 abstract "Currently viewed as a complementary non-pharmacological intervention for preventing cardiac disorders, long-term aerobic training produces cardioprotection through remote ischemic preconditioning (RIPC) mechanisms. However, RIPC triggered by acute exercise remains poorly understood. Although resistance exercise (RE) has been highly recommended by several public health guidelines, there is no evidence showing that RE mediates RIPC. Hence, we investigated whether RE induces cardiac RIPC through nitric oxide synthase (NOS)-dependent mechanism.Acute RE at 40% of the maximal load augmented systemic nitrite levels, associated with increased cardiac eNOS phosphorylation, without affecting nNOS activity. Using an experimental model of myocardial infarction (MI) through ischemia-reperfusion (IR), RE fully prevented the loss of cardiac contractility and the extent of MI size compared to non-exercised (NE) rats. Moreover, RE mitigated aberrant ST-segment and reduced life-threatening arrhythmias induced by IR. Importantly, inhibition of NOS abolished the RE-mediated cardioprotection. After IR, NE rats showed increased cardiac eNOS activity, associated with reduced dimer/monomer ratio. Supporting the pivotal role of eNOS coupling during MI, non-exercised rats displayed a marked generation of reactive oxygen species (ROS) and oxidative-induced carbonylation of proteins, whereas RE prevented these responses. We validated our data demonstrating a restoration of physiological ROS levels in NE + IR cardiac sections treated with BH4, a cofactor oxidatively depleted during eNOS uncoupling, while cardiac ROS generation from exercised rats remained unchanged, suggesting no physiological needs of supplemental eNOS cofactors.Together, our findings strongly indicate that RE mediates RIPC by limiting eNOS uncoupling and mitigates myocardial IR injury." @default.
- W2897054691 created "2018-10-26" @default.
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- W2897054691 date "2018-12-01" @default.
- W2897054691 modified "2023-09-25" @default.
- W2897054691 title "Resistance exercise mediates remote ischemic preconditioning by limiting cardiac eNOS uncoupling" @default.
- W2897054691 cites W1511302815 @default.
- W2897054691 cites W1887722354 @default.
- W2897054691 cites W1970842881 @default.
- W2897054691 cites W1977183875 @default.
- W2897054691 cites W1988198174 @default.
- W2897054691 cites W1991445432 @default.
- W2897054691 cites W1994270731 @default.
- W2897054691 cites W1995749170 @default.
- W2897054691 cites W2010217891 @default.
- W2897054691 cites W2012073884 @default.
- W2897054691 cites W2012488407 @default.
- W2897054691 cites W2012517632 @default.
- W2897054691 cites W2023421218 @default.
- W2897054691 cites W2040324649 @default.
- W2897054691 cites W2040603631 @default.
- W2897054691 cites W2041417763 @default.
- W2897054691 cites W2061616701 @default.
- W2897054691 cites W2062777516 @default.
- W2897054691 cites W2086700179 @default.
- W2897054691 cites W2091684885 @default.
- W2897054691 cites W2094949453 @default.
- W2897054691 cites W2096492016 @default.
- W2897054691 cites W2098329072 @default.
- W2897054691 cites W2101047147 @default.
- W2897054691 cites W2104083428 @default.
- W2897054691 cites W2107554716 @default.
- W2897054691 cites W2117571600 @default.
- W2897054691 cites W2120200123 @default.
- W2897054691 cites W2122179672 @default.
- W2897054691 cites W2124112181 @default.
- W2897054691 cites W2129462206 @default.
- W2897054691 cites W2139219244 @default.
- W2897054691 cites W2143004446 @default.
- W2897054691 cites W2146217294 @default.
- W2897054691 cites W2151607481 @default.
- W2897054691 cites W2159756111 @default.
- W2897054691 cites W2169002616 @default.
- W2897054691 cites W2171952998 @default.
- W2897054691 cites W2197894983 @default.
- W2897054691 cites W2253078664 @default.
- W2897054691 cites W2257751750 @default.
- W2897054691 cites W2281735941 @default.
- W2897054691 cites W2321727237 @default.
- W2897054691 cites W2473965540 @default.
- W2897054691 cites W2505569242 @default.
- W2897054691 cites W2513659121 @default.
- W2897054691 cites W2552665596 @default.
- W2897054691 cites W2584172352 @default.
- W2897054691 cites W2609319132 @default.
- W2897054691 cites W2613412363 @default.
- W2897054691 cites W2621044226 @default.
- W2897054691 cites W2739907642 @default.
- W2897054691 cites W2744105079 @default.
- W2897054691 cites W2760540656 @default.
- W2897054691 cites W2768251835 @default.
- W2897054691 cites W2775127991 @default.
- W2897054691 cites W2781553996 @default.
- W2897054691 cites W2785925223 @default.
- W2897054691 cites W2793022961 @default.
- W2897054691 cites W2793046954 @default.
- W2897054691 cites W2914053210 @default.
- W2897054691 doi "https://doi.org/10.1016/j.yjmcc.2018.10.016" @default.
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