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- W2897055765 endingPage "172" @default.
- W2897055765 startingPage "155" @default.
- W2897055765 abstract "To avert toxicity, to prolong drug action, and to enhance in vivo drug concentrations and stability, various drug carriers are used today. Nanotechnology uses silver, gold, and carbon (fullerenes) nanoparticles to target bacterial, plant, and animal cells with great success. DNA molecules are composed of pentose deoxy sugars, phosphate, and organic nitrogenous bases (adenine, cytosine, thymine, guanine) and are stable as a solid or in solution. DNA is also a good carrier of electrons and is biocompatible, with binding efficiency to many organic biomolecules, proteins, and metal ions. More importantly, DNA itself has the inherent property of being able to condense many folds, as in chromosomes, giving compact structures. Thus DNA molecules can be arranged into a variety of nanostructures in the size range of 10–100 nm under special conditions, for example, 90°C–20°C–4°C transitions in the presence of 0–20 mM MgCl2, due to electrostatic attraction among the free electrons of the sugar and phosphate oxygen and base nitrogen, as well as having various cohesive or sticky ends or loop structures among oligonucleotide staple strands. Thus, DNA tiles and DNA origami in the presence of DNA aptamers are used in various modes of 3D DNA nanotubes as drug carriers for efficient delivery to target organs and cells. Multidrug-resistant infections have reported tremendously increasing minimal inhibitory concentrations (MICs) due to the accumulation of 5–15 mdr genes (bla, aac, aad, aph) and many drug efflux genes (tet, acrAB, mexCD, macAB) in conjugative plasmids. DNA nanocarriers are excellent for increasing the in vivo drug concentration to defeat the increased MICs of antibiotics in superbug infections. DNA nanoparticles may bring a revolution in medical science to overcome drug toxicity with targeted drug delivery in different disease forms." @default.
- W2897055765 created "2018-10-26" @default.
- W2897055765 creator A5036641878 @default.
- W2897055765 date "2019-01-01" @default.
- W2897055765 modified "2023-09-27" @default.
- W2897055765 title "Nucleic Acid-Based Nanocarriers" @default.
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