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- W2897056819 abstract "Mdn1 is an essential AAA (ATPase associated with various activities) protein that removes assembly factors from distinct precursors of the ribosomal 60S subunit. However, Mdn1’s large size (∼5,000 amino acid [aa]) and its limited homology to other well-studied proteins have restricted our understanding of its remodeling function. Here, we present structures for S. pombe Mdn1 in the presence of AMPPNP at up to ∼4 Å or ATP plus Rbin-1, a chemical inhibitor, at ∼8 Å resolution. These data reveal that Mdn1’s MIDAS domain is tethered to its ring-shaped AAA domain through an ∼20 nm long structured linker and a flexible ∼500 aa Asp/Glu-rich motif. We find that the MIDAS domain, which also binds other ribosome-assembly factors, docks onto the AAA ring in a nucleotide state-specific manner. Together, our findings reveal how conformational changes in the AAA ring can be directly transmitted to the MIDAS domain and thereby drive the targeted release of assembly factors from ribosomal 60S-subunit precursors." @default.
- W2897056819 created "2018-10-26" @default.
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- W2897056819 date "2018-10-01" @default.
- W2897056819 modified "2023-10-10" @default.
- W2897056819 title "Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis" @default.
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- W2897056819 doi "https://doi.org/10.1016/j.cell.2018.09.015" @default.
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