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- W2897059100 abstract "Abstract Introduction and aims Lynch-like syndrome is diagnosed when there is an expression deficit in DNA mismatch repair proteins but a normal genetic study. The behavior and management of that pathology are currently a subject of debate. We present herein the characteristics of patients with Lynch-like syndrome, together with a surveillance proposal. Materials and methods Immunohistochemistry was carried out on families suspected of presenting with Lynch syndrome. Germline analysis was done if there was loss of mismatch repair protein expression and no BRAF mutation. Results Of the 148 patients that underwent immunohistochemistry testing, 23 presented with loss of mismatch repair protein expression. Seven of those patients were identified as having Lynch-like syndrome: 3 had colon cancer, 2 had endometrial tumor, and 2 were healthy, with an affected relative. Mean patient age was 56.9 years and only one patient presented with another tumor associated with Lynch syndrome. Conclusions Until there is a better understanding of the etiology of that heterogeneous entity, intermediate surveillance is an adequate strategy." @default.
- W2897059100 created "2018-10-26" @default.
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- W2897059100 date "2018-10-01" @default.
- W2897059100 modified "2023-10-01" @default.
- W2897059100 title "Diagnosis and clinical behavior in patients with Lynch-like syndrome" @default.
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- W2897059100 doi "https://doi.org/10.1016/j.rgmxen.2018.06.012" @default.
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