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• W2897059776 abstract "Four new aromatic butenolides, asperimides A-D (1-4), together with a known analogue, butyrolactone I (5), were isolated from solid cultures of a tropical endophytic fungus Aspergillus terreus. The structures of these compounds were elucidated on the basis of spectroscopic methods and electronic circular dichroism calculations. Compounds 1-4 represent the first examples of butenolides with a maleimide core isolated from Aspergillus sp. Inhibitory effects of the isolated compounds on nitric oxide production were investigated in lipopolysaccaride (LPS)-mediated RAW 264.7 cells. Compounds 3 and 4 exhibited potent anti-inflammatory with IC50 values of 0.78 ± 0.06 and 1.26 ± 0.11 μM, respectively." @default.
• W2897059776 created "2018-10-26" @default.
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• W2897059776 date "2018-11-01" @default.
• W2897059776 modified "2023-10-14" @default.
• W2897059776 title "Asperimides A–D, anti-inflammatory aromatic butenolides from a tropical endophytic fungus Aspergillus terreus" @default.
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• W2897059776 doi "https://doi.org/10.1016/j.fitote.2018.10.011" @default.
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