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• W2897060792 abstract "The dipeptidyl peptidase-4 (DPP-4) inhibitor, is recommended for treatment of type 2 diabetes mellitus in the event of unresponsiveness to metformin. The DPP-4 enzyme plays vital roles in the regulation of human immunity and metabolism. In silico studies have shown that actinodaphnine has a better interaction with the DPP-4 enzyme than sitagliptin, a DPP-4 inhibitor. Actinodaphnine is found in the C. australis plant and is often used to relieve pain and fever, to lower blood pressure, and to inhibit microbial growth. This study aimed to investigate the inhibitory effect of the ethanol extract from C. australis on DPP-4 activity in a model breast cancer cell line, MCF-7. A total of 1 x 106 MCF-7 cells were grown for 24 h and then divided into the control groups (CG): negative CG (NCG) with no treatment, positive CG (PCG) with 541.7 µg/mL sitagliptin, and solvent CG (SCG) with 0.057% dimethyl sulfoxide. Furthermore, the treatment group (TGEC) was given 568.75 µg/mL ethanol extract of C. australis, and all cells were then incubated for a further 48 h. A precursor of actinodaphnine, boldine was used as a standard to measure its concentration in C. australis extract using liquid chromatography tandem-mass spectrometry. DPP-4 activity was measured using a colorimetric substrate (H-Gly-Pro-pNA) at 405 nm and calculated using the Beer-Lambert formula. Additionally, all collected data were analyzed using a one-way analysis of variance test with α = 0.05. It was found that a higher DPP-4 activity was observed in SCG (418.55 ± 134.00 nmol/minute/mg protein), compared to the NCG (232.06 ± 69.56 nmol/minute/mg protein), TGEC (214.74 ± 109.21 nmol/minute/mg protein), and PCG (214.47 ± 50.96 nmol/minute/mg protein). However, it was not a statistically significant difference (p > 0.05). In conclusion, C. australis-extracted actinodaphnine can inhibit DPP-4 activity in the MCF-7 cell line." @default.
• W2897060792 created "2018-10-26" @default.
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• W2897060792 date "2018-01-01" @default.
• W2897060792 modified "2023-10-12" @default.
• W2897060792 title "Inhibition effect of Cuscuta australis ethanol extract containing actinodaphnine on dipeptidyl peptidase-4 enzyme activity in the MCF-7 cell line" @default.
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• W2897060792 doi "https://doi.org/10.1063/1.5062727" @default.
• W2897060792 hasPublicationYear "2018" @default.
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