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• W2897060929 abstract "The neuromodulatory effects of GABA on pyramidal neurons are mediated by GABA B receptors (GABA B Rs) that signal via a conserved G-protein-coupled pathway. Two prominent effectors regulated by GABA B Rs include G-protein inwardly rectifying K + (GIRK) and P/Q/N type voltage-gated Ca 2+ (Ca V 2) ion channels that control excitability and synaptic output of these neurons, respectively. Regulator of G-protein signaling 7 (RGS7) has been shown to control GABA B effects, yet the specificity of its impacts on effector channels and underlying molecular mechanisms is poorly understood. In this study, we show that hippocampal RGS7 forms two distinct complexes with alternative subunit configuration bound to either membrane protein R7BP (RGS7 binding protein) or orphan receptor GPR158. Quantitative biochemical experiments show that both complexes account for targeting nearly the entire pool of RGS7 to the plasma membrane. We analyzed the effect of genetic elimination in mice of both sexes and overexpression of various components of RGS7 complex by patch-clamp electrophysiology in cultured neurons and brain slices. We report that RGS7 prominently regulates GABA B R signaling to Ca V 2, in addition to its known involvement in modulating GIRK. Strikingly, only complexes containing R7BP, but not GPR158, accelerated the kinetics of both GIRK and Ca V 2 modulation by GABA B Rs. In contrast, GPR158 overexpression exerted the opposite effect and inhibited RGS7-assisted temporal modulation of GIRK and Ca V 2 by GABA. Collectively, our data reveal mechanisms by which distinctly composed macromolecular complexes modulate the activity of key ion channels that mediate the inhibitory effects of GABA on hippocampal CA1 pyramidal neurons. SIGNIFICANCE STATEMENT This study identifies the contributions of distinct macromolecular complexes containing a major G-protein regulator to controlling key ion channel function in hippocampal neurons with implications for understanding molecular mechanisms underlying synaptic plasticity, learning, and memory." @default.
• W2897060929 created "2018-10-26" @default.
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• W2897060929 date "2018-10-12" @default.
• W2897060929 modified "2023-10-16" @default.
• W2897060929 title "Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7" @default.
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• W2897060929 doi "https://doi.org/10.1523/jneurosci.1378-18.2018" @default.
• W2897060929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6234300" @default.
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