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• W2897063268 abstract "EBV has been reported to impair monocyte in vitro differentiation into dendritic cells (DCs) and reduce cell survival. In this study, we added another layer of knowledge to this topic and showed that these effects correlated with macroautophagy/autophagy, ROS and mitochondrial biogenesis reduction. Of note, autophagy and ROS, although strongly interconnected, have been separately reported to be induced by CSF2/GM-CSF (colony stimulating factor 2) and required for CSF2-IL4-driven monocyte in vitro differentiation into DCs. We show that EBV infects monocytes and initiates a feedback loop in which, by inhibiting autophagy, reduces ROS and through ROS reduction negatively influences autophagy. Mechanistically, autophagy reduction correlated with the downregulation of RAB7 and ATG5 expression and STAT3 activation, leading to the accumulation of SQSTM1/p62. The latter activated the SQSTM1-KEAP1- NFE2L2 axis and upregulated the anti-oxidant response, reducing ROS and further inhibiting autophagy. ROS decrease correlated also with the reduction of mitochondria, the main source of intracellular ROS, achieved by the downregulation of NRF1 and TFAM, mitochondrial biogenesis transcription factors. Interestingly, mitochondria supply membranes and ATP required for autophagy execution, thus their reduction may further reduce autophagy in EBV-infected monocytes. In conclusion, this study shows for the first time that the interconnected reduction of autophagy, intracellular ROS and mitochondria mediated by EBV switches monocyte differentiation into apoptosis, giving new insights into the mechanisms through which this virus reduces immune surveillance. Abbreviations: ACTB: actin beta; ATG5: autophagy related 5; BAF: bafilomycin A1; BECN1: beclin 1; CAT: catalase; CSF2: colony stimulating factor 2; CT: control; CYCS (cytochrome C: somatic); DCs: dendritic cells; EBV: Epstein-Barr virus; GSR: glutathione-disulfide reductase; KEAP1: kelch like ECH associated protein 1; IL4: interleukin 4; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MET: metformin; NAC: N-acetylcysteine; NFE2L2/NRF2 nuclear factor: erythroid 2 like 2; NRF1 (nuclear respiratory factor 1); clPARP1: cleaved poly(ADP-ribose) polymerase; Rapa: Rapamycin; ROS: reactive oxygen species; SQSTM1/p62: sequestosome 1; TFAM: (transcription factor A: mitochondrial); TUBA1A: tubulin alpha 1a." @default.
• W2897063268 created "2018-10-26" @default.
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• W2897063268 date "2018-10-23" @default.
• W2897063268 modified "2023-10-11" @default.
• W2897063268 title "EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation" @default.
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• W2897063268 cites W1531634155 @default.
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• W2897063268 cites W1740603564 @default.
• W2897063268 cites W1902035320 @default.
• W2897063268 cites W1919712230 @default.
• W2897063268 cites W1969524738 @default.
• W2897063268 cites W1971088057 @default.
• W2897063268 cites W1977616453 @default.
• W2897063268 cites W1978941584 @default.
• W2897063268 cites W1981276113 @default.
• W2897063268 cites W1992486817 @default.
• W2897063268 cites W1999730899 @default.
• W2897063268 cites W2002061608 @default.
• W2897063268 cites W2002619136 @default.
• W2897063268 cites W2004325124 @default.
• W2897063268 cites W2005194145 @default.
• W2897063268 cites W2011808930 @default.
• W2897063268 cites W2014752961 @default.
• W2897063268 cites W2015614892 @default.
• W2897063268 cites W2021092016 @default.
• W2897063268 cites W2025374138 @default.
• W2897063268 cites W2026525843 @default.
• W2897063268 cites W2027236817 @default.
• W2897063268 cites W2027253055 @default.
• W2897063268 cites W2030456165 @default.
• W2897063268 cites W2030865745 @default.
• W2897063268 cites W2034786597 @default.
• W2897063268 cites W2040611423 @default.
• W2897063268 cites W2043809682 @default.
• W2897063268 cites W2054610125 @default.
• W2897063268 cites W2069050894 @default.
• W2897063268 cites W2073432389 @default.
• W2897063268 cites W2081057817 @default.
• W2897063268 cites W2081100233 @default.
• W2897063268 cites W2081920342 @default.
• W2897063268 cites W2082762381 @default.
• W2897063268 cites W2084063309 @default.
• W2897063268 cites W2085328785 @default.
• W2897063268 cites W2085363039 @default.
• W2897063268 cites W2087561593 @default.
• W2897063268 cites W2096745640 @default.
• W2897063268 cites W2110873896 @default.
• W2897063268 cites W2114806766 @default.
• W2897063268 cites W2117848441 @default.
• W2897063268 cites W2121077787 @default.
• W2897063268 cites W2124420768 @default.
• W2897063268 cites W2127600445 @default.
• W2897063268 cites W2132763961 @default.
• W2897063268 cites W2134907909 @default.
• W2897063268 cites W2135650439 @default.
• W2897063268 cites W2140751228 @default.
• W2897063268 cites W2142655750 @default.
• W2897063268 cites W2144522321 @default.
• W2897063268 cites W2148281700 @default.
• W2897063268 cites W2153013045 @default.
• W2897063268 cites W2163510698 @default.
• W2897063268 cites W2170597525 @default.
• W2897063268 cites W2195174090 @default.
• W2897063268 cites W2268072246 @default.
• W2897063268 cites W2275315944 @default.
• W2897063268 cites W2285047614 @default.
• W2897063268 cites W2313930706 @default.
• W2897063268 cites W2475074325 @default.
• W2897063268 cites W2481461473 @default.
• W2897063268 cites W2526219494 @default.
• W2897063268 cites W2528258774 @default.
• W2897063268 cites W2591925184 @default.
• W2897063268 cites W2604630852 @default.
• W2897063268 cites W2611475096 @default.
• W2897063268 cites W2752326209 @default.
• W2897063268 cites W2783142245 @default.
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• W2897063268 doi "https://doi.org/10.1080/15548627.2018.1536530" @default.
• W2897063268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6526866" @default.
• W2897063268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30324853" @default.
• W2897063268 hasPublicationYear "2018" @default.
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