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- W2897064782 abstract "Individuals with primary age-related tauopathy (PART) have neurofibrillary tangles in regions comparable to early/moderate-stage Alzheimer's disease (AD), absent of amyloid plaques. Few studies have investigated the clinical diagnoses among individuals with PART. We aimed to: 1) describe the primary and contributing diagnoses in individuals with PART; 2) compare clinical diagnoses in those with PART versus AD neuropathology (ADNP); and 3) examine if individuals with PART less frequently receive a clinical AD diagnosis than those with ADNP. We used data on 1,354 participants from the National Alzheimer's Coordinating Center's Uniform Data Set (UDS) and Neuropathology Data Set, restricting to those with no neuritic plaques (i.e., PART) or moderate/frequent neuritic plaques (i.e., ADNP); a UDS visit within two years of autopsy; no major co-pathologies; and mild cognitive impairment (MCI) or dementia at last visit. Analyses were stratified by cognitive status at last visit (MCI or dementia). To assess if PART participants were significantly less likely to receive a primary or contributing clinical diagnosis of AD at their last visit, we used multivariable logistic regression, controlling for age at death, sex, education, and presence of ≥1 apolipoprotein e4 allele. The PART sample included 49 individuals with MCI and 112 with dementia, and the ADNP sample included 75 with MCI and 1,118 with dementia. Primary clinical diagnoses of AD were more common in those with ADNP (MCI: 69%, demented: 86%) than PART (MCI: 57%; demented: 52%). Among demented participants, primary clinical diagnoses of PPA/bvFTD or vascular brain injury/vascular dementia were more common in those with PART than ADNP. Contributing clinical diagnoses of depression were more common in those with PART than ADNP. In the adjusted analysis, primary/contributing clinical diagnoses of AD remained less likely in PART versus ADNP participants with dementia (odds ratio: 0.22, 95% confidence interval: 0.13-0.38). Although there are no accepted in vivo diagnostic criteria for PART, this study suggests that clinicians may recognize the distinction between PART and ADNP when making clinical diagnoses, diagnosing AD less frequently in those with PART. Nonetheless, clinical AD was diagnosed 50% of the time in PART participants with MCI or dementia." @default.
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- W2897064782 date "2018-07-01" @default.
- W2897064782 modified "2023-10-16" @default.
- W2897064782 title "P1‐499: CLINICAL DIAGNOSES AMONG INDIVIDUALS WITH PRIMARY AGE‐RELATED TAUOPATHY VERSUS ALZHEIMER'S NEUROPATHOLOGY" @default.
- W2897064782 doi "https://doi.org/10.1016/j.jalz.2018.06.509" @default.
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