Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897065161> ?p ?o ?g. }
- W2897065161 endingPage "1199" @default.
- W2897065161 startingPage "1191" @default.
- W2897065161 abstract "Currently delivered light dose (J/cm2) is the principal parameter guiding interstitial photodynamic therapy (I-PDT) of refractory locally advanced cancer. The aim of this study was to investigate the impact of light dose rate (irradiance, mW/cm2) and associated heating on tumour response and cure.Finite-element modeling was used to compute intratumoural irradiance and dose to guide Photofrin® I-PDT in locally advanced SCCVII in C3H mice and large VX2 neck tumours in New Zealand White rabbits. Light-induced tissue heating in mice was studied with real-time magnetic resonance thermometry.In the mouse model, cure rates of 70-90% were obtained with I-PDT using 8.4-245 mW/cm2 and ≥45 J/cm2 in 100% of the SCCVII tumour. Increasing irradiance was associated with increase in tissue heating. I-PDT with Photofrin® resulted in significantly (p < 0.05) higher cure rate compared to light delivery alone at same irradiance and light dose. Local control and/or cures of VX2 were obtained using I-PDT with 16.5-398 mW/cm2 and ≥45 J/cm2 in 100% of the tumour.In Photofrin®-mediated I-PDT, a selected range of irradiance prompts effective photoreaction with tissue heating in the treatment of locally advanced mouse tumour. These irradiances were translated for effective local control of large VX2 tumours." @default.
- W2897065161 created "2018-10-26" @default.
- W2897065161 creator A5003685309 @default.
- W2897065161 creator A5004485473 @default.
- W2897065161 creator A5011623946 @default.
- W2897065161 creator A5024968992 @default.
- W2897065161 creator A5028399591 @default.
- W2897065161 creator A5031498565 @default.
- W2897065161 creator A5036627287 @default.
- W2897065161 creator A5054903525 @default.
- W2897065161 creator A5059519859 @default.
- W2897065161 creator A5065629135 @default.
- W2897065161 creator A5068759406 @default.
- W2897065161 creator A5069146590 @default.
- W2897065161 creator A5083433515 @default.
- W2897065161 date "2018-10-24" @default.
- W2897065161 modified "2023-10-12" @default.
- W2897065161 title "Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer" @default.
- W2897065161 cites W1587997752 @default.
- W2897065161 cites W1880827019 @default.
- W2897065161 cites W2000144812 @default.
- W2897065161 cites W2005813498 @default.
- W2897065161 cites W2013011469 @default.
- W2897065161 cites W2015879048 @default.
- W2897065161 cites W2020464162 @default.
- W2897065161 cites W2021580977 @default.
- W2897065161 cites W2030389627 @default.
- W2897065161 cites W2033290447 @default.
- W2897065161 cites W2036996291 @default.
- W2897065161 cites W2042669918 @default.
- W2897065161 cites W2070605499 @default.
- W2897065161 cites W2077984066 @default.
- W2897065161 cites W2093919938 @default.
- W2897065161 cites W2094192722 @default.
- W2897065161 cites W2106062609 @default.
- W2897065161 cites W2112845420 @default.
- W2897065161 cites W2114571271 @default.
- W2897065161 cites W2115598036 @default.
- W2897065161 cites W2134556168 @default.
- W2897065161 cites W2139122813 @default.
- W2897065161 cites W2142576861 @default.
- W2897065161 cites W2151734986 @default.
- W2897065161 cites W2151757047 @default.
- W2897065161 cites W2153439641 @default.
- W2897065161 cites W2196156382 @default.
- W2897065161 cites W2281651064 @default.
- W2897065161 cites W2314662748 @default.
- W2897065161 cites W2328912513 @default.
- W2897065161 cites W2335758191 @default.
- W2897065161 cites W2463804954 @default.
- W2897065161 cites W2529484692 @default.
- W2897065161 cites W2580285549 @default.
- W2897065161 cites W2587754963 @default.
- W2897065161 cites W2602907503 @default.
- W2897065161 cites W2753616731 @default.
- W2897065161 cites W4249649453 @default.
- W2897065161 doi "https://doi.org/10.1038/s41416-018-0210-y" @default.
- W2897065161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6251027" @default.
- W2897065161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30353043" @default.
- W2897065161 hasPublicationYear "2018" @default.
- W2897065161 type Work @default.
- W2897065161 sameAs 2897065161 @default.
- W2897065161 citedByCount "31" @default.
- W2897065161 countsByYear W28970651612019 @default.
- W2897065161 countsByYear W28970651612020 @default.
- W2897065161 countsByYear W28970651612021 @default.
- W2897065161 countsByYear W28970651612022 @default.
- W2897065161 countsByYear W28970651612023 @default.
- W2897065161 crossrefType "journal-article" @default.
- W2897065161 hasAuthorship W2897065161A5003685309 @default.
- W2897065161 hasAuthorship W2897065161A5004485473 @default.
- W2897065161 hasAuthorship W2897065161A5011623946 @default.
- W2897065161 hasAuthorship W2897065161A5024968992 @default.
- W2897065161 hasAuthorship W2897065161A5028399591 @default.
- W2897065161 hasAuthorship W2897065161A5031498565 @default.
- W2897065161 hasAuthorship W2897065161A5036627287 @default.
- W2897065161 hasAuthorship W2897065161A5054903525 @default.
- W2897065161 hasAuthorship W2897065161A5059519859 @default.
- W2897065161 hasAuthorship W2897065161A5065629135 @default.
- W2897065161 hasAuthorship W2897065161A5068759406 @default.
- W2897065161 hasAuthorship W2897065161A5069146590 @default.
- W2897065161 hasAuthorship W2897065161A5083433515 @default.
- W2897065161 hasBestOaLocation W28970651611 @default.
- W2897065161 hasConcept C120665830 @default.
- W2897065161 hasConcept C121332964 @default.
- W2897065161 hasConcept C121608353 @default.
- W2897065161 hasConcept C126322002 @default.
- W2897065161 hasConcept C142724271 @default.
- W2897065161 hasConcept C178790620 @default.
- W2897065161 hasConcept C185592680 @default.
- W2897065161 hasConcept C2780192828 @default.
- W2897065161 hasConcept C2781323092 @default.
- W2897065161 hasConcept C2781469039 @default.
- W2897065161 hasConcept C2989005 @default.
- W2897065161 hasConcept C46423501 @default.
- W2897065161 hasConcept C71924100 @default.
- W2897065161 hasConcept C75473681 @default.
- W2897065161 hasConceptScore W2897065161C120665830 @default.