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• W2897066615 startingPage "1467" @default.
• W2897066615 abstract "LC3 is a protein that can associate with autophagosomes, autolysosomes, and phagosomes. Here, we show that LC3 can also redistribute toward the damaged Golgi apparatus where it clusters with SQSTM1/p62 and lysosomes. This organelle-specific relocation, which did not involve the generation of double-membraned autophagosomes, could be observed after Golgi damage was induced by various strategies, namely (i) laser-induced localized cellular damage, (ii) local expression of peroxidase and exposure to peroxide and diaminobenzidine, (iii) treatment with the Golgi-tropic photosensitizer redaporfin and light, (iv) or exposure to the Golgi-tropic anticancer peptidomimetic LTX-401. Mechanistic exploration led to the conclusion that both reactive oxygen species-dependent and -independent Golgi damage induces a similar phenotype that depended on ATG5 yet did not depend on phosphatidylinositol-3-kinase catalytic subunit type 3 and Beclin-1. Interestingly, knockout of ATG5 sensitized cells to Golgi damage-induced cell death, suggesting that the pathway culminating in the relocation of LC3 to the damaged Golgi may have a cytoprotective function." @default.
• W2897066615 created "2018-10-26" @default.
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• W2897066615 date "2018-10-22" @default.
• W2897066615 modified "2023-10-18" @default.
• W2897066615 title "Recruitment of LC3 to damaged Golgi apparatus" @default.
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• W2897066615 doi "https://doi.org/10.1038/s41418-018-0221-5" @default.
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• W2897066615 hasPublicationYear "2018" @default.
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